Extraction of wild jujube seed oil and preparation of soft capsule and function on central nervous system

A technology of jujube seed oil and jujube kernel, which can be used in nervous system diseases, capsule delivery, medical preparations containing active ingredients, etc., and can solve the problem of high process cost

Inactive Publication Date: 2004-04-28
XI AN JIAOTONG UNIV
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Problems solved by technology

The above-mentioned patents have disadvantages such as high process cost, and the supercritical carbon dioxide extraction method requires special equipment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] 1. Determining that Suanzaoren oil is an effective part of the central nervous system of Suanzaoren

[0009] The jujube seed oil was saponified and methylated, and the fatty oil and betulinic acid were extracted and separated to obtain unsaponified products, methyl esterified products, fatty oil and betulinic acid crystals of the jujube kernel oil; the above products of the jujube kernel oil were The pharmacological activity screening of the sedative effect showed that, except the non-saponification products of the wild jujube seed oil were inactive, the fatty oil and betulinic acid all had a sedative effect at the same dose of the wild jujube kernel oil, indicating that the effective part of the wild jujube kernel for sedation and hypnosis It may be fatty acids and betulinic acid dissolved in fatty acids. The experimental results are shown in Table 1.

[0010] Table 1 Effects of unsaponifiable matter, methylated product and betulinic acid of jujube seed oil on spontane...

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Abstract

The present invention provides the extraction of wild jujube seed oil, the preparation of soft capsule and the function on central nervous system. The extraction of wild jujube seed oil includes squeezing wild jujube seed in squeezer to obtain dregs and coarse oil; mixing the dregs and petroleum ether to obtain refined oil after recovering petroleum ether; dissolving the coarse oil and petroleum ether to obtain refined oil after recovering petroleum ether; merging refined oil, heating in evaporating pot to eliminate residual solvent and water and to obtain wild jujube seed oil. The preparation of soft wild jujube seed oil capsule includes soaking gelatin, heating in water bath, adding glycerin and Nipagin A, and filtering to obtain gelatin liquid; preparing gelatin plate with the gelatin liquid; sandwiching wild jujube seed oil with two gelatin plates and pressing with steel mold. Research shows that wild jujube seed oil has tranquilizing, hypnotic, memory-promoting and anxiety resisting effects, and may be used in treating neurosis and insomnia.

Description

1. Technical field [0001] The invention relates to a preparation process and application of a medicine, in particular to the extraction of jujube seed oil, the preparation of soft capsules and the effect on the central nervous system. 2. Background technology [0002] Suanzaoren is a traditional Chinese medicinal material commonly used to nourish the heart and calm the nerves, and is mostly used in Chinese medicine compound prescriptions. It is generally believed that the water-soluble part of Suanzaoren - total glycosides of Suanzaoren is the effective part of Suanzaoren's effect on the central nervous system. Sour date oil is often discarded as an inactive part. Existing patent applications: 1) The formula and preparation method of Suanzaoren Oil Jiangzhi Dropping Pills (94107184), which includes the preparation of Suanzaoren Oil Dropping Pills and the use of blood lipid regulation; 2) Supercritical carbon dioxide extraction method to extract Suanzaoren Oil and Jujube Se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61P25/20A61P25/22
Inventor 袁秉祥
Owner XI AN JIAOTONG UNIV
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