Hemsleya amabilis drip pill and its preparation method

A technology for snow bilulin and dropping pills, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It solves the problems of long solution time, and achieves the effects of convenient carrying and taking, improved dissolution rate and dissolution rate, and small pill volume.

Inactive Publication Date: 2004-05-05
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, only gentianin tablets are sold in the market, which not only has a single dosage form, but also has a long disintegration time, low dissolution rate and dissolution rate, poor absorption and bioavailability due to the insoluble water and strong hydrophobicity of gentianin tablets. The dosage is low, the amount of excipients is large, it is inconvenient to take for children, the elderly, bedridden patients and patients with dysphagia, and the compliance is poor, which affects the therapeutic effect of cecumin.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0065] prescription:

[0066] Snow colloid 5g

[0067] Macrogol 6000 15g

[0068] Makes 1000 capsules

[0069] Preparation method: take the fine powder of ichoranthin that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by dropping, dry, and obtain .

example 2

[0071] prescription:

[0072] Snow colloid 5g

[0073] Macrogol 4000 15g

[0074] Makes 1000 capsules

[0075] Preparation method: Take the fine powder of ichoranthin that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry to obtain .

example 3

[0077] prescription:

[0078] Snow colloid 5g

[0079] Macrogol 6000 5g

[0080] Macrogol 4000 10g

[0081] Makes 1000 capsules

[0082] Preparation method: Take the fine powder of ichoranthin that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone oil as the coolant, and make it dropwise The legal pills are dried and obtained immediately.

[0083] 4. Example 4

[0084] prescription:

[0085] Snow colloid 5g

[0086] Glyceryl monostearate 15g

[0087] Makes 1000 capsules

[0088] Preparation method: Take the fine powder of galactin that has passed through a 200-mesh sieve and add it to the molten glyceryl monostearate matrix, mix well, use ice water as the cooling agent, make pellets by drop method, and dry to obtain.

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PUM

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Abstract

A dripping pill of hemsleyadine and its superfine pulverizing process for preparing it are disclosed. Its advantages are high dissolving and disintegrating speed, high stripping percentage, quickly taking its effect high stability and low cost.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to gentianin dripping pills and a preparation method thereof. Background technique [0002] Hemsleyadinum (Hemsleyadinum) is a mixture of Hemsleyadinum and Hemsleyadinum extracted from the Cucurbitaceae plant Hemsleyadinum, mainly Hemsleyadinum, which has the functions of clearing away heat, detoxification, antibacterial and anti-inflammatory. Clinically used for bacillary dysentery, enteritis, bronchitis, acute tonsillitis. [0003] At present, only gentianin tablets are sold in the market, which not only has a single dosage form, but also has a long disintegration time, low dissolution rate and dissolution rate, poor absorption and bioavailability due to the insoluble water and strong hydrophobicity of gentianin tablets. The dosage is low, the amount of excipients is large, it is inconvenient to take for children, the elderly, bedridden patients and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/57A61P1/00A61P11/00A61P11/04A61P31/04
Inventor 钱进许军彭红李平刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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