Miniaturized oligonucleotide chip for sort diagnosis of head and neck squamous cell carcinoma

A technology of miniaturized oligonucleotides and squamous cell carcinoma, applied in the field of miniaturized oligonucleotide chips, can solve the problems of lack of effective and unified methods, and achieve the goals of reliable algorithm, high test sensitivity, and accurate early molecular classification diagnosis Effect

Inactive Publication Date: 2004-11-10
上海第二医科大学附属第九人民医院
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Problems solved by technology

[0003] Since biochip technology is a newly emerging field, how to analyze the data obtained by biochip technology still lacks an effective and unified method

Method used

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Embodiment Construction

[0010] A miniaturized oligonucleotide chip for the molecular classification and diagnosis of head and neck squamous cell carcinoma referred to in the present invention, which consists of some gene sequences significantly related to head and neck squamous cell carcinoma to form corresponding oligonucleotide probes, and is prepared into a miniaturized diagnostic chip , characterized in that the probes are the following oligonucleotide sequences, representing 39 genes in total, including: EMP1, CEACAM5, NA, ZNF185, ACPP, COL1A2, HPGD, TGM3, ITGA6, NMU, OPN, SCEL, COL1A1 , COL4A2, KRT13, PPL, PP11, CYP3A5, PLAU, IL1RN, PITX1, MAL, BLNK, FN1, COL5A2, MMP1, MFAP2, SERPINH2, COL4A1, KRT4, LAGY, C5ORF13, FAPA, SPINK5, KIAA0790, DUSP5, PTHLH, GPX3 , CEACAM1.

[0011] The molecular classification method for head and neck squamous cell carcinoma referred to in the present invention relates to establishing the molecular classification standard for head and neck squamous cell carcinoma; co...

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Abstract

The invention relates to a miniaturized oligonucleotide chip for classified diagnosis of head and neck squamous cancer cell molecules, as well as a classified diagnosis method of head and neck squamous cancer cell molecules, using some gene orders remarkably relative to head and neck squamous cancer to compose the corresponding oligonucleotide probe and prepare miniaturized diagnosis chip. It replaces high-flux large chip with miniaturized diagnosis chip, remarkably reducing cost and simplifying operating courses. This special chip is obtained by multiple statistic analysis standards and combination of statistic methods: intersection of an and B gene groups and COM frame (C gene group). By synthetically using these methods, it retains the advantages of high sensitivity of different statistic methods (parameter / nonparameter / mixed parameter, differential average value / average value difference) and overcomes the false positive persecution caused by different statistic methods.

Description

technical field [0001] The invention relates to a miniaturized oligonucleotide chip for molecular classification diagnosis of head and neck squamous cell carcinoma and a method for molecular classification diagnosis of head and neck squamous cell carcinoma. Background technique [0002] Head and neck squamous cell carcinoma is a kind of polygenic, multi-step disease. Since the cancer in this part is mostly located in or close to important tissues and organs (such as the brain, upper respiratory tract, mastication, speech, hearing, vision and important nerves and blood vessels), the safe range of surgical resection is severely restricted, and most patients after treatment There is obvious dysfunction and disfigurement. At the end of the 20th century, the 5-year survival rate of oral and maxillofacial cancer patients reached about 60%, but the 5-year survival rate of advanced patients was only 20-40%. This is closely related to the heterogeneity and biological behavior of tu...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
Inventor 陈万涛张萍张志愿邱蔚六张陈平竺涵光孙坚李江
Owner 上海第二医科大学附属第九人民医院
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