Bacterin of nucleic acid for anti atherosclerosis and preparation method

A technology for atherosclerotic nucleic acid and nucleic acid vaccines, which is applied in pharmaceutical formulations, antibody medical ingredients, and medical preparations containing active ingredients, etc., and can solve the problem of patients' lack of long-term compliance, long-term use, diet and exercise are not always effective And other issues
CN1562349AInactive Publication Date: 2005-01-12CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2005-01-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

A nucleic acid vaccine for preventing and treating atherosolerosis and its preparing process are disclosed. The core protein of hepatitis B is used as its immune carrier to intensify the immunogenicity of CETPC. The body immunized by said vaccine can generate CETPC antibody to suppress the activity of cholesteryl ester transfer protein, so decreasing the generation of atherosclerosis spots. It can also act on the formed atherosclerosis sports to relay them.
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Description

technical field

[0001] In the medical field, the anti-atherosclerosis nucleic acid vaccine provided by the invention can be used for preventing and treating atherosclerosis. Background technique

[0002] Atherosclerosis (AS) is a common vascular disease caused by degenerative and proliferative lesions of the arteries, resulting in thickening of the vessel wall, loss of elasticity and narrowing of the lumen. Thin and complex carbohydrates are deposited, accompanied by smooth muscle cells and fibrous tissue proliferation, and then the intima and media gradually degenerate and calcify. The disease mainly involves large muscular elastic arteries (such as the aorta) and medium-sized muscular elastic arteries (coronary arteries and cerebral arteries are the most affected). Functional disorders, among which coronary heart disease caused by coronary atherosclerosis, that is, coronary heart disease, is the most common type of organ lesions caused by the disease. The incidence rate ...

Claims

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