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Preparation of amidated natural metha camphor as effective algefacient

A technology of cooling agent and menthol, which is applied in the field of preparation of new high-efficiency cooling agent amidated menthol, can solve the problems of development and application limitations, low conversion rate, etc., achieve better effect, increase whiteness, and reduce production cost Effect

Inactive Publication Date: 2005-05-11
TIANFA FINE CHEM HARBIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low conversion rate, the development and application of this process is limited

Method used

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  • Preparation of amidated natural metha camphor as effective algefacient
  • Preparation of amidated natural metha camphor as effective algefacient
  • Preparation of amidated natural metha camphor as effective algefacient

Examples

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Effect test

Embodiment 1

[0023] Preparation of N-ethyl-p-menthane-3-carboxamide

[0024] 1. Preparation of Chloromenthane

[0025] Add ZnCl to the reaction flask 2 / HCl saturated solution, introduce HCl gas under stirring, add menthol crystals, continue stirring for 2-3h, when the conversion rate (GC) reaches above 97%, the reaction ends. Distilled under reduced pressure to obtain menthane chloride with a yield of 95% and a purity of 97% (GC).

[0026] 2. Preparation of Magnesium Chloromenthane

[0027] The reaction was carried out in a reaction flask equipped with magnetic stirring. Weigh the quantitatively treated magnesium bars and add them to the reaction bottle, add anhydrous ether and initiator, stir the reaction, add dropwise the mixture composed of chloromenthane and anhydrous ether, the dropping time is about 1 hour, after the dropwise addition is completed The reaction was continued for 2-3h, and the reaction was completed, and the reaction mixture was directly used for the next reaction...

Embodiment 2

[0035] Preparation of N-tert-butyl-p-menthane-3-carboxamide

[0036] Substitute tert-butylamine for monoethylamine and follow the steps above to prepare N-tert-butyl-p-menthane-3-carboxamide with a purity of 97%, a melting point of 94-96°C and a whiteness of 94.

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Abstract

Production of freshener-amido natural mentha camphor is carried out by chloro reacting, format reacting, acidifying, acyl chloride reacting, acidamide reacting and annealing. It achieves high purity.

Description

Technical field [0001] The invention belongs to additives, in particular to a preparation method of amidated menthol, a novel high-efficiency cooling agent. Background technique [0002] As we all know, menthol has a physiological cooling effect on the skin and oral mucosa, and is widely used as a spice (menthol is the main component of peppermint oil) in food, beverages, toothpaste, chewing gum and other products. It is also used in products such as toilet cleaners and lotion products. In addition, menthol is also widely used in tobacco products as a spice, which can produce a cool feeling in the mouth when people smoke. [0003] It has been determined that the cooling effect of menthol is due to a physiological effect of menthol acting directly on the nerve endings of the body that respond to heat and cold, rather than due to latent heat evaporation. It can be considered that menthol acts on the nerve endings first, and then transmits the stimulation to the central nervo...

Claims

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Application Information

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IPC IPC(8): C07C233/58
Inventor 郑伟骆希明朱传勇陈为民
Owner TIANFA FINE CHEM HARBIN
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