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Method for preparing total biological alkali extract of korean aconite roof and use

A technology for total alkaloids and extracts is applied in the field of preparation and application of total alkaloid extracts of Guanbaifu, which can solve the problems of large loss of raw materials, long extraction process cycle, failure to make full use of Guanbaifu resources, and the like, Achieve high separation efficiency and good effect

Inactive Publication Date: 2005-12-21
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the extraction rate of Guanfu A is about 0.1%, the extraction process cycle is long, the loss of raw materials is large, and the resources of Guanfu A have not been fully utilized.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take Aconitum coreanum (Lèvl.) Rapaics dry root tuber powder 500g, reflux extraction with 95% ethanol twice, recover the extract to obtain 84g extract, add 2% hydrochloric acid to acidify to pH4, and extract three times with ethyl acetate to obtain The extract A and the sour water mother liquor, the sour water mother liquor was basified with ammonia water to pH 10, and then extracted 3 times with ethyl acetate to obtain the extract B and the sour water mother liquor, the extract B was concentrated to obtain 23 g of extract, and the extract Add it to the treated D605 macroporous adsorption resin column, elute with water and 80% ethanol successively, collect the ethanol eluate, and distill to dryness under reduced pressure to obtain 15 g of total alkaloid extract.

Embodiment 2

[0032] Take Aconitum coreanum (Lèvl.) Rapaics dry root tuber powder 600g, methanol reflux extraction 3 times, recover the extract to obtain 95g extract, add acetic acid to acidify to pH3, extract 2 times with chloroform to obtain extract A and jellyfish The sour water mother liquor was basified with sodium carbonate to pH 11, and then extracted 3 times with chloroform to obtain the extract B and the alkaline water mother liquor. The extract B was concentrated to obtain 35 g of extract, which was added to the treated D140 On a macroporous adsorption resin column, eluted with water and methanol in sequence, collected the methanol eluate, and distilled to dryness under reduced pressure to obtain 24 g of total alkaloid extract.

[0033] According to the patent application whose authorization number is CN1039198C, and according to the basic method of pharmacy, the total alkaloids of Guanbaifu can be prepared into intramuscular injection, intravenous injection, powder injection, free...

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PUM

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Abstract

On the basis of not reducing the drug effect, in order to make the most of utilizing monkshood resources of our country, through investigation, have separated and got total alkaloid extracts from monkshood, among them the content of alkaloid is more than 50 percent. The basis of medicine is Guan-Fu base or homolog equal activity even stronger, making the extact of monkshood total alkaloid to agents has offered an anti-arrhythmia medicine which is cheap, safety, take medicine handy for clinic; pharmacology experiment has improved it.

Description

[0001] purpose of invention [0002] On the basis of not reducing the efficacy, in order to make full use of the existing resources of Guanbaifu in my country, after research, the total alkaloid extract was isolated from Guanbaizhong, in which the alkaloid content was over 50%, and the main component was Guanfujia The preparation of the total alkaloid extract of Guanbaifu can provide low-cost, safe, effective, and convenient antiarrhythmic drugs for clinical use; the pharmacological experiments have preliminarily studied the effect of the total alkaloid extract. Antiarrhythmic effect. Background technique: [0003] Guanbaifu total alkaloid extract is the first effective part in my country to extract from Aconitum coreanum (Lèvl.) Rapaics root Guanbaizhong with a total alkaloid content greater than 50%; Guanbaifu is a commonly used traditional Chinese medicine, modern pharmacology Scientific studies have shown that the main components of Guanfuzhong, Guanfujia, Guanfuheptadin, Gu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/08
Inventor 刘静涵蒋凯杨春华汤庆发王吓长
Owner CHINA PHARM UNIV
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