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Spray containing Vitamin D analog

A vitamin and spray technology, which is applied in the field of medicine, can solve the problems such as the decrease of the first spray drug dose, the unfavorable drug delivery system, and the inability to spray smoothly, and achieve the effects of simple production process, convenient use and good pharmacy performance.

Inactive Publication Date: 2006-02-15
晏四平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the volatility of ethanol, the liquid medicine may be concentrated in the liquid delivery pipeline of the spray pump, causing the nozzle to be blocked and unable to spray smoothly; decline, which is detrimental for drug delivery systems

Method used

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  • Spray containing Vitamin D analog
  • Spray containing Vitamin D analog
  • Spray containing Vitamin D analog

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] prescription:

[0165] Vitamin D 2 0.25g

[0166] LABRAFAC CC add to 100ml

[0167] Preparation method: take vitamin D 2 , Add about 50ml of LABRAFAC CC, stir to dissolve, add LABRAFAC CC to 100ml, stir evenly, filter with a dry G6 vertical melting glass filter, dispense into spray bottles, screw the spray pump, and get it.

Embodiment 2

[0169] prescription:

[0170] Vitamin D 3 10g

[0171] Peppermint oil 0.5g

[0172] 98% ethanol 40g

[0173] 1,2-Propanediol 9.5g

[0174] LABRAFAC CC add to 100ml

[0175] Preparation method: take vitamin D 3 , Add ethanol, propylene glycol and peppermint oil, then add 40g of LABRAFAC CC, stir to dissolve, add LABRAFAC CC to 100ml, stir evenly, filter with a dry G6 vertical melting glass filter, dispense into the spray bottle, tighten the spray pump , That is.

Embodiment 3

[0177] prescription:

[0178]Alfacalcidol 0.5mg

[0179] Peppermint oil 0.7g

[0180] Milk chocolate flavor 1g

[0181] LABRAFAC CC add to 100ml

[0182] Preparation method: Take Alfacalcidol, add about 50g of LABRAFAC CC, peppermint oil, milk chocolate flavor, stir to dissolve, add LABRAFAC CC to 100ml, stir evenly, filter with a dry G6 vertical melting glass filter, and dispense into the spray Tighten the spray pump in the bottle to get it.

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Abstract

The invention relates to a spray containing Vitamin D analog, wherein the medicinal solution comprises, (1) one or more vitamin D analog, (2) fatty medicinal solution carrier, the vitamin D analog is represented by formula (I). The spray has good pharmaceutical property and high stability.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine and relates to a spray, in particular to a spray containing vitamin D analogues. 【Background technique】 [0002] Vitamin D analogs, including Vitamin D 2 , Vitamin D 3 , calcifediol, calcitriol, alfacalcidol, dihydrotachysterol, etc. They all have similar chemical structures and pharmacological effects. The dosage forms of this class of drugs currently on the market in various countries in the world include oral tablets, hard capsules, soft capsules (capsules), etc., and injections. A prominent feature of the above-mentioned substances is that they all have very strong physiological activities, that is, a small amount of drugs can produce strong physiological effects, such as the vitamin D listed in the 2005 edition of the Chinese Pharmacopoeia. 2 and vitamin D 3 The size of the capsules is about 25-250 μg per capsule, the calcitriol capsules, calcitriol capsules, and alfacalcidol tablets o...

Claims

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Application Information

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IPC IPC(8): A61K31/59A61K9/12A61P3/02
Inventor 周华英
Owner 晏四平
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