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Composition for preventing or treating allergic disease using black rice extract and its therapeutic use

A technology for allergic diseases and extracts, applied in allergic diseases, drug combinations, sensory diseases, etc., can solve problems such as unexplained effects

Inactive Publication Date: 2006-06-07
TG LIFE IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the specific role of each compound in anthocyanins has not been elucidated

Method used

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  • Composition for preventing or treating allergic disease using black rice extract and its therapeutic use
  • Composition for preventing or treating allergic disease using black rice extract and its therapeutic use
  • Composition for preventing or treating allergic disease using black rice extract and its therapeutic use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The preparation of black rice extract

[0077] Black rice (produced in Korea, Jingdong Market, Seoul, Korea) was pulverized, 100% ethanol was added thereto, and extracted at 35° C. for 7 hours. The obtained extract was evaporated and the residue was freeze-dried to obtain powdered black rice extract.

Embodiment 2

[0078] Detection of the inhibitory effect of black rice extract on asthma

[0079] In this example, an experiment was conducted to investigate whether black rice extract could suppress allergic asthma by suppressing inflammation in mice with ovalbumin-induced asthma.

[0080] First, in order to prepare an animal model of asthma, 20 10-week-old female mice (C57BL / 6, Damul Science, Daejeon, Korea) in the abdominal cavity. Two weeks later, each mouse was sensitized by spraying with 200 μl ovalbumin solution (2% w / v (weight / volume)). On the 21st day, 22nd day, and 23rd day, they were sprayed with 200 μl of 1% ovalbumin solution, and on the 25th day, they were sprayed with 10% ovalbumin solution for sensitization.

[0081] The above-mentioned mice sensitized with 10% ovalbumin to induce asthma were divided into two groups, one group was used as a negative control without any reagent treatment, and the other group was treated with 10 mg / kg black rice extract. Black rice extract ...

Embodiment 3

[0083] The effect of the saffron contained in the black rice extract on the accumulation of eosinophils in the airway

[0084] The main component of the black rice extract having the above-mentioned asthma suppressing effect is an anthocyanin compound. In this example, through experiments, it is studied whether anthocyanins, the main active components of the black rice extract, can inhibit asthma, and which anthocyanins can indeed inhibit asthma.

[0085] The mouse asthma was induced by the same method as in Example 2 above, and then the mice were divided into four groups, one group was used as a negative control, and the other three groups were used as an experimental group, and methylanthocyanidin, delphinidin And flower sunflower (0.5mg / kg, 1.25mg / kg) treatment. Compounds of each group were administered by intraperitoneal injection, and mice were given two injections on day 24 and day 25 after treatment with ovalbumin.

[0086] The day after treatment, each mouse was kil...

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Abstract

The invention relates to a composition for preventing or treating allergic diseases by using black rice extract and the therapeutic application of the composition. More specifically, the present invention relates to a composition for preventing or treating allergic diseases, which composition contains the following substances as active ingredients: pelargonidin, cyanidin glycoside or containing pelargonidin and Black rice extract of anthocyanins; the invention also relates to the therapeutic use of said composition. Anthocyanin, anthocyanin or black rice extract containing anthocyanin and anthocyanin inhibit the aggregation of eosinophils in the tissue, and thus have an inhibitory effect on allergic inflammation, so the above substances can be effectively For the prevention or treatment of allergic diseases associated with inflammation and eosinophil accumulation, such as allergic rhinitis, allergic conjunctivitis, asthma, chronic obstructive pulmonary disease, atopic dermatitis, allergic Sexual diarrhea etc.

Description

technical field [0001] The invention relates to a composition for preventing or treating allergic diseases by using black rice extract and the therapeutic use of the composition. More specifically, the present invention relates to a composition for preventing or treating allergic diseases, which composition contains the following substances as active ingredients: pelargonidin, cyanidin glycoside or containing pelargonidin and Black rice extract of anthocyanins; the invention also relates to the therapeutic use of said composition. Background technique [0002] Generally, allergic diseases are known to be caused by allergic inflammation in tissues such as airways or bronchi. In particular, allergic diseases are caused by the entry of allergens (antigens) such as dust, pollen, fungi, various foods, and drugs into the individual through respiratory organs, digestive organs, or skin, and then attach to the surface of mast cells in tissues IgE (immunoglobulin E) antibody binds,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/353A61K31/7048A61K36/00A61K36/88A61K36/899A61P37/00A61P37/08H04M1/23
CPCA61K31/352A61K31/353A61K31/7048A61K36/88A61K36/899A61P1/00A61P11/00A61P27/02A61P27/16A61P37/00A61P37/08
Inventor 金宰弘
Owner TG LIFE IND
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