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Therapeutic agent

A technology of therapeutic agent and preventive agent, applied in food preparation, food science, application, etc., can solve problems such as the anti-diabetic effect of phthaloketone compounds and the anti-obesity effect of insulin-like compounds

Inactive Publication Date: 2006-08-09
TAKARA HOLDINGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Phthalone compounds are known to have anticonvulsant effects, but so far, phthaloketone compounds have not been known to have insulin-like effects such as anti-diabetic effects and anti-obesity effects

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0456] The preparation of embodiment 1 yellow angelica alcohol

[0457] (1) Add 15L of ethanol to 5kg of dry powder of ashitaba root, extract at room temperature for 30 minutes, and separate into ethanol extract and residue after suction filtration. The residue was subjected to the same extraction twice, and then the ethanol extracts were combined and concentrated under reduced pressure to obtain an ethanol extract concentrate.

[0458] (2) The ethanol extraction concentrate obtained in Example 1-(1) was dissolved in 2 L of 25% ethanol aqueous solution, and then fractionated by reverse phase chromatography. The resin was eluted sequentially with 1 L of 30% ethanol aqueous solution, 5 L of 40% ethanol aqueous solution, 4 L of 75% ethanol aqueous solution, and 3 L of 100% ethanol aqueous solution using Cosmosil 140 C18-OPN (manufactured by Nakalai Tesque Co., Ltd.: 400 mL).

[0459] (3) The 75% ethanol aqueous eluted fraction obtained in Example 1-(2) was concentrated under red...

Embodiment 24

[0462] The preparation of embodiment 24-hydroxydrysin

[0463] The silica gel fractions No. 10-15 obtained in Example 1-(3) were collected, concentrated under reduced pressure, and then dissolved in chloroform. Then, recrystallization was performed with hexane, and the formed precipitate and supernatant were separated. The resulting precipitate was dried to yield 4-hydroxydrisin.

Embodiment 3

[0464] The preparation of embodiment 3 yellow angelica alcohol H

[0465] (1) The fraction eluted with 40% ethanol aqueous solution obtained in Example 1-(2) was concentrated under reduced pressure and adsorbed on silica gel (350 mL). According to the solvent ratio of chloroform:methanol: 50:1 (960mL), 40:1 (520mL), 20:1 (1000mL), 10:1 (840mL), 5:1 (520mL), the elution was carried out in sections , the eluate was graded by 8mL each.

[0466] (2) The silica gel fractions No. 142-164 obtained in Example 3-(1) were collected, concentrated under reduced pressure, and then dissolved in ethyl acetate. Then, recrystallization was performed with hexane, and the formed precipitate and supernatant were separated. The resulting precipitate was dried to give angelica alcohol H in yellow.

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PUM

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Abstract

A therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of a chalcone compound, an acetophenone compound, a coumarin compound, a phthalide compound, derivatives thereof, and pharmacologically acceptable salts thereof.

Description

technical field [0001] The present invention relates to medicine, food, beverage or feed that can be used for treating or preventing diseases related to insulin in organisms, such as diabetes or obesity. Background technique [0002] Insulin is a hormone necessary for the normal metabolism of carbohydrates, proteins and fats in mammals. People with type 1 diabetes cannot produce enough insulin, the life-sustaining hormone, in their bodies, and must be given insulin from the outside in order to survive. Patients with type 2 diabetes have inappropriate blood sugar levels due to insufficient insulin production, insulin resistance, etc. In order to control blood sugar levels to an appropriate level, insulin or drugs that promote insulin secretion are required. However, among patients with type 2 diabetes mellitus, for patients with diabetes whose etiology is hyperinsulinemia or insulin resistance caused by insulin receptor abnormalities or insulin receptor downstream signaling ...

Claims

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Application Information

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IPC IPC(8): A61K31/121A61K31/222A61K31/343A61K31/341A61K31/365A61K31/351A61K31/381A61K31/366A61K31/352A61P43/00A61P3/10A61P3/08A61P5/50C07D493/08C07D309/12C07D311/32C07C49/84C07C49/835C07C69/18C07C69/157C07C69/16C07C205/45A23L1/30C07D307/80C07D307/46C07D307/88C07D333/16C07D407/14C07D311/58
Inventor 榎龙嗣小林英二小川衣子工藤庸子田边雅茂杉山胜美大野木宏佐川裕章加藤郁之进
Owner TAKARA HOLDINGS
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