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Preparation technology of yellow arsenic nano-particle

A preparation process and nanoparticle technology, applied in the field of preparation technology of orpiment nanoparticles, can solve the problems of low bioavailability, large dosage, strong toxic and side effects and the like

Inactive Publication Date: 2006-08-30
SOUTHEAST UNIV
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Problems solved by technology

Some scholars have reported that orpiment plays an important role in inhibiting the growth and inducing apoptosis of acute promyelocytic leukemia (acutepromyelocytic leukemia, APL), breast cancer, and ovarian cancer cell lines. However, the clinical application and basic research of orpiment are currently limited to the traditional dosage form with large particles, and there are problems such as large dosage, low bioavailability, and strong toxic and side effects in clinical practice. Long-term or high-dose use can also cause a variety of diseases. Therefore, if we can improve the traditional preparation process and use modern technology to prepare new dosage forms of arsenic-containing traditional Chinese medicine to improve its bioavailability, enhance curative effect, reduce drug dosage, and reduce its toxic and side effects, it will be of great significance. important clinical significance

Method used

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  • Preparation technology of yellow arsenic nano-particle
  • Preparation technology of yellow arsenic nano-particle
  • Preparation technology of yellow arsenic nano-particle

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Embodiment Construction

[0024] Prepare As 2 o 3 Hydrochloric acid solution and thioacetamide (TAA) solution: As 2 o 3 Mix it with hydrochloric acid at a ratio of 33:1 per milligram of mass and per milliliter volume, and heat it in a constant temperature water bath at 60°C to dissolve it completely to obtain liquid A; mix thioacetamide and H 2 O is fully mixed and dissolved at a ratio of 37.5:1 per milligram of mass to per milliliter volume to obtain liquid B. Under magnetic stirring, the ratio of ethanol to liquid A volume is (19-79):1. solution was added dropwise into ethanol, mixed evenly to obtain solution C, and continued to stir for 5-10 minutes after dropping; under magnetic stirring, the volume ratio of solution B to solution C was 1: (20-80) to mix B Add solution dropwise to solution C, continue to stir for 5-10 minutes after dropping, bath in water at 50°C-60°C until the solution becomes cloudy, that is, the solution is lemon yellow, and orpiment nanoparticles with a particle size of 60nm...

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Abstract

A medicine Cihuang nanoparticle for treating tumor is prepared from As2O3, thioacetylamine (TAA), hydrochloric acid and absolute alcohol as solvent through reaction at a certain temp.

Description

technical field [0001] The invention relates to a new dosage form of traditional drug orpiment for treating tumors, in particular to a preparation process of orpiment nanoparticles. Background technique [0002] Orpiment is an important arsenic-containing mineral traditional Chinese medicine and an important arsenic raw material for industrial use. Its main component is As 2 S 3 , Insoluble in water, also insoluble in dilute hydrochloric acid. At present, people use the flotation method to extract relatively high-purity orpiment from arsenic-containing ores. The particle size of orpiment produced by this method is relatively large. Larger flaws. Some scholars have reported that orpiment plays an important role in inhibiting the growth and inducing apoptosis of acute promyelocytic leukemia (acutepromyelocytic leukemia, APL), breast cancer, and ovarian cancer cell lines. However, the clinical application and basic research of orpiment are currently limited to the tradition...

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Application Information

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IPC IPC(8): A61K33/36A61K9/14A61P35/00
Inventor 张东生林梅王子妤
Owner SOUTHEAST UNIV
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