Method for preparing Chinese herbs or natural product to make extract component stable
A technology of natural products and Chinese medicinal materials, applied in the field of blending, can solve problems such as inflexible conditions for the quality of blended materials, backlog of funds, and failure to provide restrictions on the proportion of blended materials
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Embodiment 1
[0137] Embodiment 1: adopt the method of the present invention to blend the salvia miltiorrhiza raw material and ensure that the content of its extract index components is stable
[0138] Salvia miltiorrhiza is the main raw material of Danshen injection water injection and powder injection, and also an important raw material of other injections such as Xiangdan injection. In this example, salvianolic acid B, danshensu, and protocatechualdehyde are listed as index components that need to be controlled in content. A total of 58 batches of wild and cultivated Danshen medicinal materials were collected and purchased nationwide, including 14 wild batches and 44 planted batches. The medicinal materials were identified by the Institute of Traditional Chinese Medicine and Natural Products.
[0139] The goal of setting this embodiment is to investigate whether the raw material blending method of the present invention can ensure that the index component content Cm of the extract after t...
Embodiment 2
[0281] Embodiment 2: Adopt the method of the present invention to blend the salvia miltiorrhiza raw material and ensure that the content of its extract index components is stable
[0282] In order to fully reflect the application effect of the present invention, the purpose of setting this example is to illustrate that the present invention can impose mandatory requirements on the amount of raw materials and allow different upper and lower limit deviations of component content in the constraint conditions.
[0283] The symbols in this embodiment have the same meanings as those in Embodiment 1. Step 1 of this embodiment is the same as that of Embodiment 1, that is, Cs=(3.63 0.49 0.074) T . Step 2 of this embodiment sets c l =(0.08 0.10 0.16) T , c u =(0.20 0.10 0.08) T , at this time the allowable ranges of the contents of the three components are different; the similarity constraint is not considered. Step 3 of this embodiment is the same as that of Embodiment 1, and the...
Embodiment 3
[0287] Embodiment 3: Using the method of the present invention to blend the salvia miltiorrhiza raw material and ensure that the content of the index components of the extract is stable
[0288] In order to fully reflect the use effect of the present invention, the goal of setting this embodiment is to illustrate the application of the present invention using different weights w for optimization. This embodiment examines the two types of optimal quality of square deviation and optimal quality of absolute value deviation. Using the objective function of weight w, consider different w values.
[0289] The symbols in this embodiment have the same meanings as those in Embodiment 1. Step 1 of this embodiment is the same as that of Embodiment 1, that is, Cs=(3.63 0.49 0.074) T . Step 2 of this embodiment is the same as that of Embodiment 2, i.e. c l =(0.08 0.10 0.16) T , c u =(0.20 0.10 0.08) T ; The similarity constraint is not considered. Step 3 of this embodiment is the sa...
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