Method for preparing Chinese herbs or natural product to make extract component stable

A technology of natural products and Chinese medicinal materials, applied in the field of blending, can solve problems such as inflexible conditions for the quality of blended materials, backlog of funds, and failure to provide restrictions on the proportion of blended materials

Inactive Publication Date: 2010-05-12
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the following disadvantages: firstly, multiple batches of extracts need to be obtained for blending, which will occupy a large storage volume, accumulate funds, and have a long production cycle
If some batches of extracts cannot be used for blending, it is easy to cause deterioration and waste of the extracts, and the production plan of the finished product is greatly affected by the condition of the extracts
In addition, the optimization goal of this blending method is not flexible enough. It does not consider the lowest cost or the best performance indicators when the quality of the blended material is qualified. The definition of qualified conditions for the blended material is not flexible enough, and there is no method to limit the proportion of the blended material.

Method used

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  • Method for preparing Chinese herbs or natural product to make extract component stable
  • Method for preparing Chinese herbs or natural product to make extract component stable
  • Method for preparing Chinese herbs or natural product to make extract component stable

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Embodiment 1: adopt the method of the present invention to blend the salvia miltiorrhiza raw material and ensure that the content of its extract index components is stable

[0138] Salvia miltiorrhiza is the main raw material of Danshen injection water injection and powder injection, and also an important raw material of other injections such as Xiangdan injection. In this example, salvianolic acid B, danshensu, and protocatechualdehyde are listed as index components that need to be controlled in content. A total of 58 batches of wild and cultivated Danshen medicinal materials were collected and purchased nationwide, including 14 wild batches and 44 planted batches. The medicinal materials were identified by the Institute of Traditional Chinese Medicine and Natural Products.

[0139] The goal of setting this embodiment is to investigate whether the raw material blending method of the present invention can ensure that the index component content Cm of the extract after t...

Embodiment 2

[0281] Embodiment 2: Adopt the method of the present invention to blend the salvia miltiorrhiza raw material and ensure that the content of its extract index components is stable

[0282] In order to fully reflect the application effect of the present invention, the purpose of setting this example is to illustrate that the present invention can impose mandatory requirements on the amount of raw materials and allow different upper and lower limit deviations of component content in the constraint conditions.

[0283] The symbols in this embodiment have the same meanings as those in Embodiment 1. Step 1 of this embodiment is the same as that of Embodiment 1, that is, Cs=(3.63 0.49 0.074) T . Step 2 of this embodiment sets c l =(0.08 0.10 0.16) T , c u =(0.20 0.10 0.08) T , at this time the allowable ranges of the contents of the three components are different; the similarity constraint is not considered. Step 3 of this embodiment is the same as that of Embodiment 1, and the...

Embodiment 3

[0287] Embodiment 3: Using the method of the present invention to blend the salvia miltiorrhiza raw material and ensure that the content of the index components of the extract is stable

[0288] In order to fully reflect the use effect of the present invention, the goal of setting this embodiment is to illustrate the application of the present invention using different weights w for optimization. This embodiment examines the two types of optimal quality of square deviation and optimal quality of absolute value deviation. Using the objective function of weight w, consider different w values.

[0289] The symbols in this embodiment have the same meanings as those in Embodiment 1. Step 1 of this embodiment is the same as that of Embodiment 1, that is, Cs=(3.63 0.49 0.074) T . Step 2 of this embodiment is the same as that of Embodiment 2, i.e. c l =(0.08 0.10 0.16) T , c u =(0.20 0.10 0.08) T ; The similarity constraint is not considered. Step 3 of this embodiment is the sa...

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Abstract

The present invention relates to a method for blending Chinese medicinal material or natural product to make its extract component content be stable. Said method includes the following steps: 1), defining target component and its content of Chinese medicinal material or natural product standard extract; 2), defining relative deviation range of its target component content when its extract qualityis acceptable after the Chinese medicinal material or natural product is blended; 3), sampling and extracting every batch of Chinese medicinal material or natural product to be blended, determining its target component content; 4), defining blending parameter, quality control parameter and blending target of Chinese medicinal material or natural product so as to form constrained optimization problem; 5), resolving constrained optimization problem to obtain optimum blending ratio; and 6), mixing Chinese medicinal material or natural product according to optimum blending ratio, making extractionso as to obtain the extract whose target component content is acceptable. Said method can be extensively used in production process of Chinese medicine, natural product, biological product, wine, beverage, health-care product, flavouring product, edible oil, fuel oil, gas and feed, etc.

Description

technical field [0001] The invention relates to a blending method, in particular to a method for blending Chinese medicinal materials or natural products to stabilize the content of extract components. Background technique [0002] Chinese medicinal materials and natural products are important sources of food, health care products, medicines, spices and chemical raw materials. China's diverse natural conditions have bred rich resources of Chinese medicinal materials and natural products. According to the statistics of "Chinese Traditional Medicine and Natural Product Resources", my country has 11,146 kinds of medicinal plants, 1,581 kinds of medicinal animals, and 80 kinds of medicinal minerals, of which more than 600 kinds are commonly used Chinese medicinal materials and natural products. Chinese herbal medicines and natural products mainly have two growth methods: artificial cultivation and wild. There are more than 200 cultivated varieties of commonly used Chinese herba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/00
Inventor 罗国安杨辉华刘永锁梁琼麟王义明
Owner TSINGHUA UNIV
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