Hysteromyoma treating suppository and its preparing method

A technique for uterine fibroids and suppositories, applied in the field of suppositories for treating uterine fibroids and their preparation, can solve the problems of slow absorption, long action time, slow onset of action and the like, and achieve fast absorption, long action time and fast onset of action. Effect

Inactive Publication Date: 2006-11-08
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] ①The drug has great toxic and side effects on the liver;
[0012] ②The drug has great irritation to the stomach;
[0013] ③ Drugs are easily destroyed by digestive juices;
[0014] ④Slow absorption, slow onset, long acting time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of the suppository of danazol of the present invention comprises the steps:

[0040] 1) Prescription:

[0041] Danazol 15g

[0042] Stearic acid 15g

[0043] Semi-synthetic fatty acid esters 120g

[0044] 2) Preparation method:

[0045] Weigh stearic acid and semi-synthetic fatty acid ester according to the above prescription, heat and melt in a water bath at 60°C; add danazol when the temperature drops to 40°C, prepare by hot-melt method, seal the package, and store in a cool place.

[0046] (1), the appearance inspection in the quality control of danazol suppository of the present invention comprises the following steps:

[0047] Properties: White to off-white, uniform and smooth, with suitable hardness.

[0048] Weight difference: each suppository weighs 2.5g, and the weight difference is ±7.5%.

[0049] Melting time limit: determined according to the method of appendix XB of the second part of the Chinese Pharmacopoeia 1995 edition, it will com...

Embodiment 2

[0057] 1) Prescription:

[0058] Danazol 20g

[0059] Stearic acid 10g

[0060] Semi-synthetic fatty acid esters 70g

[0061] 2) Preparation method:

[0062] Weigh stearic acid and semi-synthetic fatty acid ester according to the above prescription, heat and melt in a water bath at 70°C; add danazol when the temperature drops to 50°C, prepare by hot-melt method, seal the package, and store in a cool place.

[0063] Test method is the same as embodiment 1.

Embodiment 3

[0065] 1) Prescription:

[0066] Danazol 10g

[0067] Stearic acid 20g

[0068] Semi-synthetic fatty acid ester 30g

[0069] 2) Preparation method:

[0070] Weigh stearic acid and semi-synthetic fatty acid ester according to the above prescription, heat and melt in a water bath at 90°C; add danazol when the temperature drops to 35°C, prepare by hot-melt method, seal the package, and store in a cool place.

[0071] Test method is the same as embodiment 1.

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PUM

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Abstract

The present invention discloses a kind of hysteromyoma treating suppository and its preparation process. The hysteromyoma treating suppository is prepared with danozol 10-20 wt%, stearic acid 10-20 wt% and semi-synthetic fatty acid ester 60-80 wt%. The preparation process includes the following steps: heating stearic acid and semi-synthetic fatty acid ester in water bath at 60-90 deg.c; adding danozol after cooling to 40-50 deg.c; preparing in hot smelting process and sealing and packing. The present invention has the beneficial effects of: raised curative effect, reduced toxic side effect on liver of the medicine, less stimulation on stomach, etc.

Description

technical field [0001] The invention relates to a suppository for treating uterine fibroids and a preparation method thereof. Background technique [0002] Uterine fibroids (myoma of uterus) is the most common benign tumor in female reproductive organs, more common in women aged 30-50, it is estimated that about 20%-25% of women aged 35-50 suffer from uterine fibroids [1] . 335 Swiss women aged 25-40 were randomly selected, and the incidence rate of uterine fibroids was 5.4% in vaginal B-ultrasound examination. The prevalence of fibroids increases with age, 7.8% for 33-40 years old. The incidence of autopsy fibroids is 50%. Among the 10 uterine specimens undergoing hysterectomy for other reasons, the incidence of fibroids was found to be 77% in serial sections at intervals of 2 mm. Black women are three times more likely to have fibroids than white women, based on ultrasound and hysterectomy specimens. Fibroids occur in 6%-34% of women undergoing hysteroscopy for vagina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K9/02A61P15/00
Inventor 朱利民聂华丽
Owner DONGHUA UNIV
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