Technique for preparing embolism agent of granule of polyvinyl alcohol

A preparation process, polyvinyl alcohol technology, applied in the direction of medical preparations of non-active ingredients, block delivery, anti-tumor drugs, etc., can solve the problems of large and small particle aggregation, difficult to disperse, etc., and achieve economical and convenient effects

Active Publication Date: 2006-12-06
杭州艾力康医药科技有限公司
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Problems solved by technology

[0005] The deficiency of the method of the present invention is: due to drying immediately after freezing and crushing, and then sieving, the large and small particles are mixed together, and due to the electrostatic adsorption of the particles, the large and small particles are aggregated, and it is difficult to disperse them

Method used

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Examples

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Embodiment Construction

[0017] The present invention will be further described below in conjunction with the examples.

[0018] The preparation technology of this polyvinyl alcohol particle embolic agent is mainly realized by the following steps,

[0019] 1), the first freezing treatment with water for injection: in the sterile operating room, according to the aseptic operation method, put the small pieces of polyvinyl formal that have been washed with sterile water for injection into a plastic box, add sterile Water for injection, immerse all materials in it, and place it in a -40°C freezer for 12 hours to freeze all materials into hard ice cubes;

[0020] 2), shattering treatment: the ice cubes are shaved with a sterilized stainless steel ice shaver at a speed of 1400 rpm, collect the shaved ice particles, add sterilized water for injection, and then put them in -40 ℃. In the freezer, after the ice freezes into ice cubes, the ice shaver is used to shatter it, and the ice shaver is repeatedly forme...

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Abstract

A process for preparing the granular embolizing agent from polyvinyl alcohol includes such steps as dissolving polyvinyl formal in aseptic water for injection, freezing at -20--40 deg.C for 10-12 hr, planning on the obtained ice block multiple times to obtain ice particles, classifying by wet sieving by immersing the sieve in suspension to obtain wet polyvinyl formal particles, freezing again, and dry sieving for classifying.

Description

technical field [0001] The invention relates to a preparation process of an embolic agent, in particular to a preparation process of a polyvinyl alcohol particle embolic agent. Background technique [0002] Currently in medical technology, as interventional therapy becomes more mature, it is used more and more frequently. The key technology of interventional therapy is that the granular embolic agent used to block the blood supply of tumor tissue has high requirements on the size of the particles, and the foam particles are now imported from abroad, which are more expensive; The manufacturing process is the problem to be solved by the present invention. [0003] The pulverization of materials mainly uses external mechanical force, impact, crushing and grinding to destroy the cohesion between the molecules of the material, so as to achieve the purpose of pulverization. The most effective pulverizing technologies and machines at present are: (1) Impact pulverizing technology...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K9/16A61P35/00
Inventor 郑隆泗
Owner 杭州艾力康医药科技有限公司
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