Technique for preparing embolism agent of granule of polyvinyl formal

Abstract

A process for preparing the granular embolizing agent from polyvinyl alcohol includes such steps as dissolving polyvinyl formal in aseptic water for injection, freezing at -20--40 deg.C for 10-12 hr, planning on the obtained ice block multiple times to obtain ice particles, classifying by wet sieving by immersing the sieve in suspension to obtain wet polyvinyl formal particles, freezing again, and dry sieving for classifying.

Description

technical field [0001] The invention relates to a preparation process of an embolic agent, in particular to a preparation process of a polyvinyl formal particle embolic agent. Background technique [0002] At present, in medical technology, as interventional therapy becomes more and more mature, the frequency of use is also increasing. The key technology of interventional therapy is the particle embolism used to block the blood supply of tumor tissue, which has a high requirement on the size of the particle, and now the foam particles imported from abroad are more expensive; how to prepare a cheap and good particle embolism The manufacturing process of the present invention is the problem to be solved. [0003] The crushing of materials mainly uses external mechanical force, impact, crushing and grinding to destroy the cohesive force between material molecules, so as to achieve the purpose of crushing. At present, the most effective crushing technology and machinery are: (...

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Problems solved by technology

[0005] The deficiency of the method of the present invention is: due to drying immediately after freezing and crushing, and then sieving, the large and small particles are mixed together, and due to the electrostatic adsorption of the particles, the large and small particles are aggregated, and it is difficult to disperse them