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Use of -(4-hydroxy-3-methoxyphenyl)-7-(4- hydroxyphenyl)-3,5-dihydroxy heptane

A technology of methoxyphenyl and hydroxyheptane is applied in the field of extracting diarylheptane compounds from galangal, and can solve the problems such as no public reports on anti-Candida albicans.

Inactive Publication Date: 2006-12-27
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no public report about extracting anti-Candida albicans effective chemical components from galangal

Method used

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  • Use of -(4-hydroxy-3-methoxyphenyl)-7-(4- hydroxyphenyl)-3,5-dihydroxy heptane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] A method for extracting diaryl heptane compound 1-(4-hydroxyl-3-methoxyphenyl)-7-(4-hydroxyphenyl)-3,5-dihydroxyheptane from Galanga, comprising Follow the steps below:

[0010] (1) 3.5 kilograms of galangal medicinal materials are pulverized, (galangal was purchased from Tianjin Chinese Herbal Pieces Factory in March, 2004, identified by the Pharmacy Teaching and Research Office of Tianjin Medical University) plus 10 kilograms of ethanol aqueous solution with a concentration of 90% by volume, heated to reflux for 6 After 1 hour, the extract was filtered, extracted 3 times, and the filtrate was concentrated under reduced pressure to 50°C when the relative density was 1.10 extract (300g), added distilled water 4 times the mass of the extract to dissolve, extracted 3 times with chloroform, The extract was concentrated under reduced pressure to obtain 150 g of chloroform extract. The extract was separated by silica gel column chromatography (1.2 kg, 100-200 mesh), and pet...

Embodiment 2

[0015] Antibacterial activity of 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-3,5-dihydroxyheptane

[0016] compound

Embodiment 3

[0018] Combining 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-3,5-dihydroxyheptane with pharmaceutically acceptable carriers to make various dosage forms, For the treatment of diseases caused by Candida albicans.

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Abstract

The invention discloses the use of 1-(4-hydroxy-3-methoxybenzene)--7-(4-hydroxyphenyl)-3,5-dihydroxy heptane in preparing medicament for resisting candida albicans, wherein the effective constituent is obtained from conventional galangal rhizome crude slices through separating methods.

Description

technical field [0001] The invention relates to an application of extracting compounds from traditional Chinese medicines, in particular to an application of extracting diarylheptane compounds from galangal. Background technique [0002] The traditional Chinese medicine galangal is one of the commonly used traditional Chinese medicines. It has the effects of warming the stomach, expelling wind, dispersing cold, promoting qi and relieving pain. It is widely used in seasoning among the people. Clinically, it is often used in the treatment of cold pain in the abdomen, cold stomach and vomiting, indigestion, acid regurgitation and other diseases. Modern chemical and pharmacological studies have shown that galangal has complex chemical components, strong pharmacological activity, and strong anti-ulcer, anti-diarrhea, choleretic, analgesic, anti-inflammatory, anti-hypoxic, anti-coagulant, and anti-thrombotic effects. It has been clinically proven for many years that galangal has...

Claims

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Application Information

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IPC IPC(8): A61K31/085A61P31/04
Inventor 蒋伶活
Owner TIANJIN UNIV
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