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Pessary or intrauterine medicine release device containing antiestrogenic and anti-pregnant hormone composite preparation and its use

An anti-progestin and anti-estrogen technology, which can be used in medical preparations containing active ingredients, pharmaceutical formulations, and drug devices, etc. Side effects, etc.

Active Publication Date: 2010-12-29
SHANGHAI INST OF PLANNED PARENTHOOD RES +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, there have been many effective exploratory attempts to treat uterine fibroids and endometriosis with drugs, and systemic drugs such as oral or injection are often used. The side effects make it difficult for patients to adhere to medication for a long time, unable to complete the treatment cycle of drug efficacy, and finally fail, failing to achieve the purpose of treating uterine fibroids

Method used

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  • Pessary or intrauterine medicine release device containing antiestrogenic and anti-pregnant hormone composite preparation and its use
  • Pessary or intrauterine medicine release device containing antiestrogenic and anti-pregnant hormone composite preparation and its use
  • Pessary or intrauterine medicine release device containing antiestrogenic and anti-pregnant hormone composite preparation and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Weigh 300 mg of mifepristone, 200 mg of letrozole, 0.1 gram of sodium lauryl sulfate, 0.1 gram of Span-20 and 0.7 gram of β-cyclodextrin (molecular weight 1134, produced by Shanghai Reagent Company), mix well Fill it into a silastic-382 medical silicone rubber tube with a wall thickness of 1 mm, put it into a molding mold, and heat press it.

Embodiment 2

[0070] Weigh a certain amount of HTV medical rubber (molecular weight 300,000-1,000,000, produced by Shanghai Rubber Products Research Institute) and extrude and vulcanize it into a medical rubber ring with a diameter of 5 cm. Weigh 300 milligrams of mifepristone, 200 milligrams of letrozole, 0.015 grams of Brij52 and 1.2 grams of HTV medical rubber (molecular weight 300,000-1,000,000, produced by Shanghai Rubber Products Research Institute), knead and press into a 1.2-mm-thick first Thin skin, this first thin skin is coated on the above-mentioned medical rubber ring that makes; Take again 200 milligrams of Letrozole, 0.01 gram of Brij52 and 1 gram of HTV medical rubber (molecular weight 30-1,000,000, produced by Shanghai Rubber Products Research Institute) ), after kneading, it is pressed into a second thin skin with a thickness of 1.2 mm, and the second thin skin is coated on the first thin skin, and the obtained article is coated with a 0.02 mm HTV medical silicone rubber th...

Embodiment 3

[0072] Obtain the medical silicone rubber liner tube of RTV-1 (molecular weight 0.74-110,000, Shanghai Rubber Products Research Institute) with a tube diameter of 4 mm by extrusion vulcanization molding, and bend the liner tube to enclose a diameter of 5 cm hollow circle.

[0073] Weigh 300 mg of HTV medical rubber (molecular weight 30-1 million, produced by Shanghai Rubber Products Research Institute), 400 mg of mifepristone, 0.3 gram of sodium lauryl sulfate, 0.1 gram of Span-80 and 0.8 gram of PEG1200, and weigh Get 200 mg of HTV medical rubber (molecular weight 30-1 million, produced by Shanghai Rubber Products Research Institute), 250 mg of letrozole, 0.1 gram of sodium lauryl sulfate, 0.05 gram of Span-80 and 0.3 gram of PEG1200, after they are mixed respectively Each was pressed into the first thin skin and the second thin skin, which were coated on the inner liner in turn, and then the RTV-1 medical silicone rubber was pressed into a thin skin with a thickness of 0.02 ...

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Abstract

The present invention is a kind of pessary or intrauterine medicine releasing device containing one medicine part, and features the medicine part containing anti-estrogen in 40-70 weight portions and anti-progestogen in 30-60 weight portions. The present invention also provides the application of the pessary or the intrauterine medicine releasing device in preparing medicine for treating hysteromyma or endometriosis.

Description

technical field [0001] The present invention relates to vaginal rings or intrauterine drug release devices containing anti-estrogens and anti-progestogens compound preparations and their use in pharmacy. Background technique [0002] At present, there have been many effective exploratory attempts to treat uterine fibroids and endometriosis with drugs, and systemic drugs such as oral or injection are often used. The side effects of the drug make it difficult for the patient to adhere to the drug for a long time, unable to complete the treatment cycle of the drug effect reward, and finally fail, failing to achieve the purpose of treating uterine fibroids. [0003] In the Chinese patent application with the application number 01112712.0 filed by the applicant on April 21, 2001, it initially relates to 1. A vaginal ring for one or at least one drug in Nafoxidine, which provides a continuous, constant, high-quantity zero-order drug release system. [0004] The currently listed ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M31/00A61K31/56
Inventor 陈海林邵海浩陈建兴陈良康
Owner SHANGHAI INST OF PLANNED PARENTHOOD RES
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