Anhydrous composition containing an acid-acid buffer system
A buffer system and composition technology, applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., can solve the problems of not providing anhydrous compositions, low buffer capacity, etc.
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Embodiment 1-10
[0043] The compositions of Examples 1, 2, 5, 7, 9 and 10 of the present invention can be prepared as follows: First, mix carbopol and acid, mix propylene glycol and glycerin. The polyacrylic acid polymer, organic acid and fatty acid (if any) are then added to the mixture in the same vessel. The mixture is then heated to about 35°C-45°C to homogenize the mixture. The mixture was then cooled.
[0044] The compositions of Examples 3, 4, 6 and 8 of the present invention (anhydrous suppositories) can be prepared by melting the suppository base, such as polyethylene glycol and / or hydrogenated vegetable oil, by heating at about 60°C. Add acid polyacrylic acid polymer and organic acid while mixing. Mix continuously for 30 minutes or until the mixture is homogeneous. The mixture is cooled and maintained at a temperature of about 40°C to 45°C to form a suppository. Preferably, they are also prepared by adding an organic acid to a polyacrylic acid polymer and heating to about 35°C to...
Embodiment 1
[0045] Embodiment 1 (anhydrous gel)
[0046] Composition %w / w
[0047] Polyethylene glycol 1000 89.30
[0048] Kabapur 974P 4.00
[0049] Lactic acid 2.00
[0050] Stearyl Alcohol 4.70
[0051] Total 100.00
Embodiment 2
[0052] Embodiment 2 (anhydrous gel)
[0053] Composition %w / w
[0054] Polyethylene glycol 400 63.00
[0055] Kabapur 974P 5.00
[0056] Lactic acid 3.00
[0057] Stearyl Alcohol 4.00
[0058] Total 100.00
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