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Anhydrous composition containing an acid-acid buffer system

A buffer system and composition technology, applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., can solve the problems of not providing anhydrous compositions, low buffer capacity, etc.

Inactive Publication Date: 2007-04-04
MCNEIL PPC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, Robinson et al. do not provide anhydrous compositions that would allow the polymer to be neutralized upon exposure to a relatively alkaline environment
[0008] Organic acids such as acetic acid, sorbic acid, lactic acid, citric acid, tartaric acid alone and applied to the vagina will lower the pH but cannot maintain a low pH because of their low buffering capacity

Method used

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Examples

Experimental program
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Embodiment 1-10

[0043] The compositions of Examples 1, 2, 5, 7, 9 and 10 of the present invention can be prepared as follows: First, mix carbopol and acid, mix propylene glycol and glycerin. The polyacrylic acid polymer, organic acid and fatty acid (if any) are then added to the mixture in the same vessel. The mixture is then heated to about 35°C-45°C to homogenize the mixture. The mixture was then cooled.

[0044] The compositions of Examples 3, 4, 6 and 8 of the present invention (anhydrous suppositories) can be prepared by melting the suppository base, such as polyethylene glycol and / or hydrogenated vegetable oil, by heating at about 60°C. Add acid polyacrylic acid polymer and organic acid while mixing. Mix continuously for 30 minutes or until the mixture is homogeneous. The mixture is cooled and maintained at a temperature of about 40°C to 45°C to form a suppository. Preferably, they are also prepared by adding an organic acid to a polyacrylic acid polymer and heating to about 35°C to...

Embodiment 1

[0045] Embodiment 1 (anhydrous gel)

[0046] Composition %w / w

[0047] Polyethylene glycol 1000 89.30

[0048] Kabapur 974P 4.00

[0049] Lactic acid 2.00

[0050] Stearyl Alcohol 4.70

[0051] Total 100.00

Embodiment 2

[0052] Embodiment 2 (anhydrous gel)

[0053] Composition %w / w

[0054] Polyethylene glycol 400 63.00

[0055] Kabapur 974P 5.00

[0056] Lactic acid 3.00

[0057] Stearyl Alcohol 4.00

[0058] Total 100.00

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PUM

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Abstract

This invention relates to anhydrous compositions and methods of maintaining healthy vaginal pH to control vaginal odor. Such compositions may be applied to the vaginal area to lower vaginal pH and assist in maintaining such pH over a period of time.

Description

field of invention [0001] The present invention relates to compositions and methods for treating vaginal disorders where the pH is elevated above the normal, healthy pH range of 3.8-4.5. The compositions can be used to treat or ameliorate a condition that raises the pH or to treat the presence of malodor, which is often caused by an elevated pH. Additionally, the composition can be used to maintain a healthy vaginal environment. Background of the invention [0002] The normal vaginal pH range is 3.8-4.5. At this pH, the microbial flora that inhabits a healthy vagina such as lactic acid bacteria thrive. Also, at this pH, conditioned bacterial growth and adhesion to the vaginal wall are inhibited. An important function of lactic acid bacteria is to regulate the normal vaginal flora. They do this by producing lactic acid, which maintains an acidic pH, and hydrogen peroxide, which inhibits catalase-negative bacteria. [0003] Certain activities a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/78A61K31/765A61K31/185A61P15/02
CPCA61K31/74A61P15/02
Inventor N·艾哈迈德C·-J·崔
Owner MCNEIL PPC INC
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