A kind of medicine for treatment of non-gonococcal urethritis(NGU) and its preparation method

A non-gonococcal urethra and drug technology, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of unfavorable use and promotion of effective drugs, and achieve the effects of inhibiting bladder contraction and enhancing immunity

Active Publication Date: 2007-04-11
北京创立科创医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the perspective of western pharmacology research, among the three important links in the prevention and treatment of urinary tract infection, killing pathogenic bacteria, inhibiting bacterial adhesion, and improving the immune function of the body, traditional Chinese medicine has obvious advantages in the latter two aspects, but there are also some Problems to be solved urgently: For example, there are many discussions on clinical efficacy, but few experimental studies; in addition, in terms of dosage forms, decoctions are used more, and other dosage forms are less, which is not conducive to the application and promotion of effective drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] prescription:

[0110]Yellow rattan 833g King Kong rattan 833g Dandelion 833g

[0111] Phellodendron 416g, bitter wood 416g, golden grass 833g

[0112] Made into 1000 pieces

[0113] Preparation:

[0114] According to the prescription, take King Kongteng, Dandelion, Bitterwood, and Desmodium radix and add 16 times the amount of 70% ethanol to reflux and extract twice, the first time is 2 hours; the second time is 1 hour. Filtrate, combine the filtrates, recover ethanol from the filtrate under reduced pressure and concentrate to a thick paste, vacuum dry (60°C), pulverize, and pass through an 80-mesh sieve.

[0115] According to the prescription, take Huangteng and Cortex Phellodendri and grind them into coarse powder, add 0.2% sulfuric acid solution to soak (the amount of liquid just covers the surface of the medicinal material), the first time is 48 hours; the second time is 12 hours, and the third time is 12 hours. Filtrate, adjust the pH of the filtrate to 9 with...

Embodiment 2

[0118] prescription:

[0119] Yellow rattan 4165g King Kong rattan 4165g Dandelion 4165g

[0120] Phellodendron 2080g, bitter wood 2080g, golden grass 4165g

[0121] Made into 5000 pieces

[0122] Preparation:

[0123] According to the prescription, take King Kongteng, Dandelion, Bitterwood, and Desmodium radix and add 16 times the amount of 70% ethanol to reflux and extract twice, the first time is 2 hours; the second time is 1 hour. Filtrate, combine the filtrates, recover ethanol from the filtrate under reduced pressure and concentrate to a thick paste, vacuum dry (60°C), pulverize, and pass through an 80-mesh sieve.

[0124] According to the prescription, take Huangteng and Cortex Phellodendri and grind them into coarse powder, add 0.2% sulfuric acid solution to soak (the amount of liquid just covers the surface of the medicinal material), the first time is 48 hours; the second time is 12 hours, and the third time is 12 hours. Filtrate, adjust the pH of the filtrate to...

Embodiment 3

[0127] prescription:

[0128] Yellow rattan 83.3kg King Kong rattan 83.3kg Dandelion 83.3kg

[0129] Phellodendron 41.6kg Bitterwood 41.6kg Desmodium 83.3kg

[0130] Made into 100000 pieces

[0131] Preparation:

[0132] According to the prescription, take King Kongteng, Dandelion, Bitterwood, and Desmodium radix and add 16 times the amount of 70% ethanol to reflux and extract twice, the first time is 2 hours; the second time is 1 hour. Filtrate, combine the filtrates, recover ethanol from the filtrate under reduced pressure and concentrate to a thick paste, vacuum dry (60°C), pulverize, and pass through an 80-mesh sieve.

[0133] According to the prescription, take Huangteng and Cortex Phellodendri and grind them into coarse powder, add 0.2% sulfuric acid solution to soak (the amount of liquid just covers the surface of the medicinal material), the first time is 48 hours; the second time is 12 hours, and the third time is 12 hours. Filtrate, adjust the pH of the filtrate ...

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Abstract

This invention relates to the field of the Chinese traditional medical technology. It reveals a kind of medicine for treatment of non-gonococcal urethritis(NGU) and its preparation method. The medicine takes abstracts distilled from the following 6 Chinese medical ingredients as the active components: common fibraurea stem, jingangteng, dandelion herb, Chinese corktree bark, Indian quassiawood twig and leaf, snowbelleaf tickclover herb, use the above 6 ingredients to prepared the medicine by adding right weight of adjuvant material, then press them into tablets and have the tablets coated wit th thin film so to form film coated tables. Results of pharmacological researches show that the medicine of this invention has actions of excellent resisting germs, infections, benefit urination, relieving pain, expelling heat, and it can effectively reduce the infection of the urinating rout of rat. Acute and normal toxin studies show that the medicine is safe when used according the given clinical dosage.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, in particular to a medicine for treating nongonococcal urethritis and a preparation method thereof. Background technique [0002] Nongonococcal urethritis is a common sexually transmitted disease. [0003] Nongonococcal urethritis is a common and frequently occurring urinary system disorder. It is a sexually transmitted disease with an incidence rate second only to gonorrhea and condyloma acuminata. It is still on the rise. In 1998, nongonococcal urethritis was reported in my country. There are about 120,000 cases of nongonococcal urethritis patients, and with the growth of my country's floating population and the liberalization of sexual concepts, the number of nongonococcal urethritis patients is increasing rapidly. It is of practical significance to study new drugs for the treatment of nongonococcal urethritis. [0004] Western medicine believes that the disease i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/28A61P13/02
Inventor 吴梅春
Owner 北京创立科创医药技术开发有限公司
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