Slow released capsule of lindamycin sodium and bletilla tuber glue for animal and birds

A linomycin sodium, bioadhesion technology, applied in the direction of drug delivery, plant raw materials, medical preparations with inactive ingredients, etc., can solve the problem of unsatisfactory adhesion and drug release performance, dangerous disease threats, safety Not ideal and other problems, to achieve the effect of improving drug treatment effect, good treatment effect, and improving bioavailability

Inactive Publication Date: 2007-06-27
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main problems of animal products in my country are: first, the threat of dangerous diseases; second, drug residues
Natural materials are non-toxic and have good biocompatibility, but their adhesion and drug release properties are not ideal; synthetic materials have better adhesion and drug release properties, but are expensive and unsatisfactory in safety
Therefore, currently few bioadhesive materials fully meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of Linmycin Sodium Bletilla Gum Bioadhesive Sustained Release Capsules

[0014] a. Preparation of Bletilla striata gum: Bletilla striata 5kg, crushed, added 40L of distilled water, heated in a water bath at 60°C, soaked and stirred, the extract is filtered through four layers of gauze, and the medicine residue is added with distilled water, repeated dipping, combining the filtrate several times, and concentrating, Add 95% ethanol to make the alcohol content reach 70%, and a large amount of white flocculent precipitate will be deposited. Let it stand overnight, filter the next day, recover the ethanol, collect the precipitate, wash with ethanol 3 times, evaporate the ethanol, and dry at about 80°C , Weighing, smashing, you can get 1.1kg of Bletilla striata gum; Bletilla striata gum: It is yellow dry powder, tasteless and odorless, insoluble in ethanol, soluble in water, and a thick colloid. α-Naphthol concentrated sulfuric acid and alkaline copper tart...

Embodiment 2

[0016] Example 2: The prepared Linmycin sodium and Bletilla gum bioadhesive sustained-release capsules are used to treat livestock and poultry infections caused by Staphylococcus, Streptococcus pneumoniae, Escherichia coli, and typhoid bacilli. The mode of administration is mixed material or drinking water, poultry 0.05-0.1g / kg body weight, livestock 0.03-0.06g / kg body weight, twice a day, 3-5 days as a course of treatment.

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PUM

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Abstract

The present invention belongs to the field of veterinary medicine technology, and is especially slow released veterinary medicine capsule prepared with lindamycin sodium and bletilla tuber as material. The preparation process includes the following steps: water extracting and alcohol precipitating to extract bletilla tuber glue; mixing lindamycin sodium and bletilla tuber in the ratio of 1 to 3 and 10 % concentration alcohol solution of PVP as adhesive; making pellet of 20 meshes and encapsulating. The slow released veterinary medicine capsule has long medicine retaining time in the disease focus, high local medicine concentration, excellent bioadhesion and obvious medicine slow releasing characteristic.

Description

Technical field [0001] The invention belongs to the technical field of veterinary drugs, and particularly relates to the preparation of veterinary drugs linmycin sodium and Bletilla striata as raw materials to prepare veterinary drugs linmycin sodium and Bletilla gum bioadhesive sustained-release capsules and a preparation method thereof. Background technique [0002] With the development of animal husbandry in our country in the direction of intensive and intensive, the scale of animal husbandry is constantly expanding, and ensuring the quality and safety of animal husbandry products has become an important issue that we need to solve at present. At present, the main problems in my country's animal products are: first, the threat of dangerous diseases; second, drug residues. Among them, drug residues in animal food have endangered people's health. Therefore, the rational use of animal veterinary drugs and health products to control epidemics and drug residues in the process of a...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/52A61K47/36A61K31/7056A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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