Pharmaceutical composition for preventing or treating angioedema, containing extract of peony root or mixture of peony root and licorice as active ingredient

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating angioedema, containing as an active ingredient a peony root extract or an extract of a mixture of peony root and licorice. In particular, the extract of a mixture of peony root and licorice according to the present invention inhibits the excessive generation of advanced glycation end products, which may cause macular degeneration, inhibits blood-retinal barrier breakdown causing retinal edema in various animal models, protects or treats a subretinal region causing dry macular degeneration, inhibits angiogenesis causing wet macular degeneration, and thus can be usefully used as an active ingredient for the composition for preventing and treating angioedema including macular degeneration, macular edema, retinal edema, or varicose veins.

Description

RELATED APPLICATIONS[0001]This application is a National Phase of PCT Patent Application No. PCT / KR2015 / 005116 having International filing date of May 21, 2015, which claims the benefit of priority of Korean Patent Application No. 10-2014-0062201 filed on May 23, 2014. The contents of the above applications are all incorporated by reference as if fully set forth herein in their entirety.FIELD AND BACKGROUND OF THE INVENTION[0002]The present invention relates to a composition for preventing or treating angioedema, such as retinal edema, macular degeneration, and varicose veins, containing an extract of peony root or a mixed extract of peony root and licorice as an active ingredient.[0003]Angioedema is referred to as a disease that due to the increased permeability of blood vessels in the deepest recesses of skin or under skin, or beneath mucous membranes fluids flow out from the blood vessels and pool in surrounding tissues (i.e. edema is caused), and occurs well in relatively loose ...

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