Composition for preventing, alleviating, or treating cachexia and muscle loss
A technology for muscle loss and composition, applied in the field of peony root extract, can solve the problems of reducing the response rate of anti-cancer treatment, difficult to achieve anti-cancer treatment, reducing the quality of life of patients, etc., so as to reduce or treat cachexia and muscle loss, reduce Loss of appetite, weight loss effects
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Embodiment 1
[0062] Embodiment 1. Preparation of Radix Paeoniae Alba Extract
[0063] 250 g of peony roots and 2 L of 30% ethanol were placed in a 3 L reactor, and extracted under reflux at 65° C. for 4 hours using a reflux extractor. The first extract was filtered, and 2 L of 30% ethanol was added again to the residue, followed by a second extraction under the same conditions. After that, the second extract was filtered and mixed with the first extract, and then the resulting extract was concentrated at 50° C. or lower to remove ethanol. The concentrated extract was freeze-dried and then homogenized with a mixer. As a result of the preparation of the extract, Paeoniae officinalis root extract was obtained with a dry weight of 43 g (17.20% yield).
Embodiment 2
[0064] Example 2. Alleviating effect of Paeoniae officinalis root extract on tumor-induced cachexia and muscle loss
[0065] 2-1. Preparation of experimental animals and experimental methods
[0066]As experimental animals, 4-week-old male C57BL / 6 mice (weight 18 to 20 g) were purchased from Central Lab Animal Inc., allowed to acclimatize in a laboratory animal facility for 1 week, and then used for experiments. During the experiment, animals were allowed access to solid feed and water ad libitum and were housed in cages at a temperature of 22±2°C and a relative humidity of 60±5% under a 12-h light / 12-h dark cycle.
[0067] The mice were divided into a normal group (healthy group), a control group (tumor induction group), a conventional drug administration group and a peony root extract administration group, each consisting of 9 animals. Each animal in the normal group was subcutaneously injected with 100 μl of PBS (phosphate buffered saline, phosphate-buffered saline), and t...
Embodiment 3
[0098] Example 3. Alleviation of Paeoniae officinalis Root Extract on Cachexia Caused by Anticancer Drugs
[0099] 3-1. Preparation of experimental animals
[0100] As experimental animals, 4-week-old male C57BL / 6 mice (weight 18 to 20 g) were purchased from Central Lab Animal Inc., allowed to acclimatize in a laboratory animal facility for 1 week, and then used for experiments. During the experiments, animals were allowed access to solid feed and water ad libitum and were housed in cages at 22±2°C and 60%±5% relative humidity under a 12h light / 12h dark cycle.
[0101] The mice were divided into a normal group, a control group and a peony root extract-administered group, each consisting of 9 animals. For groups other than the normal (healthy) group, 5-fluorouracil (hereinafter referred to as 5-FU), an anticancer drug commonly used against digestive system cancer, was intraperitoneally administered once at a dose of 200 mg / kg to induce the anticancer drug side effect. Seven ...
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