Multi-slide assembly including slide, frame and strip cap, and methods thereof

a multi-slide, frame and strip technology, applied in the field of multi-, cell culture, immunological and molecular tools, can solve the problems of difficult to culture multiple cell lines in a single, many such cell culture vessels are not well suited for centrifugation and/or analysis, and the cell culture vessel is typically not well suited to laboratory glassware, etc., to facilitate biological testing, speed up testing, and minimize cross contamination

US20050048642A1Inactive Publication Date: 2005-03-03NALGE NUNC INTERNATIONAL
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
Publication Date
2005-03-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

A multi-slide assembly includes various components that alone or in combination facilitate testing of test samples with minimal manipulation of assay components. Moreover, the various device components permit centrifugation, culturing and analysis of each test sample to be performed in the same assembly. A frame retains a plurality of reaction vessel assemblies between a pair of opposing channels that are configured to slidably receive the opposing ends of each reaction vessel assembly. A strip cap seals the openings in each reaction vessel using cap members having sealing rings circumscribing the external walls thereof to form compression seals with internal walls of the reaction vessels. Furthermore, in a method of making a multi-well slide assembly, an ultrasonic welding process removably bonds a plurality of wells to a slide plate to provide an adequate seal therebetween during centrifugation, yet still enable separation thereof by an operator.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional application of U.S. Ser. No. 10 / 139,550, filed on May 6, 2002 by Bunn et al. (issued as U.S. Pat. No. 6,803,239), which is a divisional application of U.S. Ser. No. 09 / 510,717, filed on Feb. 22, 2000 by Bunn et al. (issued as U.S. Pat. No. 6,383,820), which is a divisional application of U.S. Ser. No. 08 / 958,521 filed on Oct. 27, 1997 by Bunn et al., (issued as U.S. Pat. No. 6,096,562) all entitled “MULTI-SLIDE ASSEMBLY INCLUDING SLIDE, FRAME AND STRIP CAP, AND METHODS THEREOF,” which applications are incorporated by reference herein.FIELD OF THE INVENTION

[0002] The invention is generally directed to cell culturing, immunological and molecular tools for use in biomedical research and diagnostics applications. More specifically, the invention is directed to cell culture, immunological and molecular tools such as slides, wells, vessels and the like for use in research or diagnostic testing of biological t...

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Embodiment Construction

[0041] Turning to the Drawing, wherein like numbers denote like parts throughout the several views, FIG. 1 is an exploded perspective view of a multi-slide assembly 10 consistent with the principles of the invention. Assembly 10 generally includes a plurality of multi-well slide assemblies 20, each including a multi-well slide 30 and a strip cap 50. Each assembly 20 may also include a lid 25 that may be used during incubation to cover each multi-well slide when its associated strip cap is removed, thus minimizing potential contamination with microorganisms, dust, etc.

[0042] The plurality of multi-well slide assemblies 20 are housed in a frame 100 that is suitable for performing batch operations on the cell cultures within the multi-well slide assemblies. Also shown is a pry-bar opener 200 that may be used to separate the upper structures of the multi-well slides from the slide plates thereof.

[0043] The discussion hereinafter will focus on cell culture applications of the invention...