Method and apparatus for selecting inlets of a multiple inlet FAIMS

Inactive Publication Date: 2005-09-08
THERMO FINNIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008] It is an object of at least some of the embodiments of the instant invention to provide ions from one ESI source to FAIMS through an active or open orifice, whilst preventing ions from another ESI source from entering FAIMS through a non-active or covered orifice.

Problems solved by technology

Multiplexing a plurality of input streams to the same detector has been attempted using a combination of ESI and MS, but such a combination is generally not very practical because the mass spectrometer is not amenable to having multiple inlets into the vacuum system.
At best, the resulting gas flow into each inlet is lower than that of one opening, but more importantly the ion optics system in the vacuum system is not generally designed to accommodate ions coming from more than one ion pathway.
Two or more inlets to the same MS is desirable, but is not generally practical.
However, the ring-shaped electrode is mechanically very difficult and inconvenient to actuate in an automated manner.
In addition, the ring-shaped electrode does not readily support introduction of ions from different ionization sources via inlet orifices that are disposed at different positions along the length of the FAIMS analyzer.

Method used

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  • Method and apparatus for selecting inlets of a multiple inlet FAIMS
  • Method and apparatus for selecting inlets of a multiple inlet FAIMS
  • Method and apparatus for selecting inlets of a multiple inlet FAIMS

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Embodiment Construction

[0036] The following description is presented to enable a person skilled in the art to make and use the invention, and is provided in the context of a particular application and its requirements. Various modifications to the disclosed embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be applied to other embodiments and applications without departing from the spirit and the scope of the invention. Thus, the present invention is not intended to be limited to the embodiments disclosed, but is to be accorded the widest scope consistent with the principles and features disclosed herein.

[0037]FIG. 1 is a schematic diagram that shows two atmospheric pressure ionization sources, in the form of a first electrospray needle 2 and a second electrospray needle 4, spraying ions toward a single-hole selector electrode 6 that is positioned adjacent and parallel to a lower plate 8 which has two openings 10 and 12 defined therethrough. Lo...

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Abstract

An ion introduction system for selecting ions from one of two separate ionization sources of ions is provided. The system includes a plate having a hole formed therethrough, the plate for being disposed adjacent an ion introduction region of a gas phase ion analyzer such that the hole is selectively movable between a first location in which the hole is adjacent to a first ionization source of ions for supporting introduction of ions from the first ionization source of ions into the gas phase ion analyzer, and a second location in which the hole is adjacent to a second ionization source of ions for supporting introduction of ions from the second ionization source of ions into the gas phase ion analyzer. The system also includes a drive mechanism for driving the plate between a first position in which the hole is at the first location and a second position in which the hole is at the second location.

Description

[0001] This application claims benefit from U.S. Provisional application 60 / 549,170 filed on Mar. 3, 2004.FIELD OF THE INVENTION [0002] This invention relates generally to High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) and more particularly to a selection system for multiple inlet FAIMS. BACKGROUND OF THE INVENTION [0003] In an analytical instrument that includes an ionization source such as for example electrospray ionization (ESI), an atmospheric pressure gas phase ion separator such as for example a high-field asymmetric waveform ion mobility spectrometer (FAIMS), and a detection system such as for example mass spectrometry (MS), it is advantageous to provide samples to the system in parallel. This allows the analytical instrument to rapidly sequence from measurements made from a first sample delivery system (HPLC for example) and from a second delivery system (preferably, but not necessarily of a type identical to the first). If the detection system is fast com...

Claims

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Application Information

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IPC IPC(8): G01N27/64H01J49/04H01J49/16H01J49/28H01J49/40H01J49/42
CPCH01J49/067G01N27/624
InventorGUEVREMONT, ROGERTHEKKADATH, GOVINDANUNNYSKOTNICKI, GREG
OwnerTHERMO FINNIGAN