Amino acid supplementation for a healthy microbiota ecosystem

a healthy microbiota and ecosystem technology, applied in the direction of peptides, dispersed delivery, transferrins, etc., can solve the problems of increasing bacterial translocation and allergy risk, affecting the integrity and function of the gut barrier, and affecting the health of the microbiota ecosystem. , to achieve the effect of restoring a healthy microbiota profil

Inactive Publication Date: 2008-11-06
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017]Another advantage of the present invention is that it provides a specific amino acid composition modulating the equilibrium of the microbiota, which is disturbed in case of psychological, physiological, or environmental stress and therefore restores a healthy microbiota profile.
is that it provides a specific amino acid composition modulating the equilibrium of the microbiota, which is disturbed in case of psychological, physiological, or environmental stress and therefore restores a healthy microbiota profile.

Problems solved by technology

An impaired balance of the ecosystem may results in impairing the gut barrier function, by reducing its protective action against pathogens attack and virulence and its beneficial stimulating action on individual's immune system.
Such alterations will impair the gut barrier integrity and function and may result in increased bacterial translocation and allergy risks.

Method used

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  • Amino acid supplementation for a healthy microbiota ecosystem
  • Amino acid supplementation for a healthy microbiota ecosystem

Examples

Experimental program
Comparison scheme
Effect test

example 1

Effect of Specific Amino Acid Supplementation on the Intestinal Microbiota

[0034]In order to test the impact of specific amino acids towards the intestinal microbiota integrity, an in vivo experiment has been set up, wherein mixtures of four different amino acids were added as supplements in the normal diet of rats exhibiting an altered intestinal microbiota.

Material and Methods

[0035]An imbalance in the intestinal microbiota was obtained using an animal model (DSS-treated rats) exhibiting common clinical and histopathological features with the human ulcerative colitis pathology (Gaudio et al., 1999).

[0036]The animal experiment was conducted as follows: Male Sprague-Dawley rats (n=32) aged 10 months were randomly distributed into 4 experimental groups (described below). During an 8 days acclimatization period, rats had free access to tap water and received a control diet or diets supplemented in amino acids as described below. After this adaptation period, Dextran Sulfate Sodium (DSS)...

example 2

Nutritional Formula

[0048]A nutritional composition for adult is prepared, and which contains for 100 g of powder: 15% of protein hydrolysate, 25% of fats, 55% carbohydrates (including maltodextrin 37%, starch 6%, sucrose 12%), traces of vitamins and oligoelements to meet daily requirements, 2% minerals and 3% moisture and 0.75 g Threonine, 1.35 g Serine, 1.2 g Proline and 0.45 g Cysteine.

[0049]13 g of this powder is mixed in 100 ml of water. The obtained formula is particularly intended for restoring or promoting intestinal microbiota in adults.

example 3

Nutritional Formula

[0050]A nutritional composition for critically ill patients, in the case of chronic diseases impacting the gut and in elderly people that present fragile ecosystem, is prepared as in example 1, but with a higher supplementation in the different amino acids. For 100 g of powder, this nutritional composition contains 1.2 g Threonine, 2.1 g Serine, 1.8 g Proline and 0.9 g Cysteine.

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Abstract

The present invention pertains to a nutritional composition for reconstituting an optimal healthy microbiota ecosystem in humans or animals. In particular, the present invention relates to an ingestible carrier containing specific amino acids designed to favor the growth of bacteria favorable to individuals health or for reducing the risk of developing deleterious events. The invention also pertains to the use of specific amino acids for reconstituting an optimal healthy microbiota ecosystem in humans or animals, in particular in infants, critically ill patients, in the case of chronic diseases or any stresses impacting the gut and in elderly people.

Description

[0001]The present invention pertains to a nutritional composition for reconstituting an optimal healthy microbiota ecosystem in humans or animals. In particular, the present invention relates to an ingestible carrier containing specific amino acids designed to favor the growth of bacteria favorable to individuals health or for reducing the risk of developing deleterious events. The invention also pertains to the use of specific amino acids for reconstituting an optimal healthy microbiota ecosystem in humans or animals, in particular in infants, critically ill patients, in the case of chronic diseases or any stresses impacting the gut and in elderly people.BACKGROUND OF THE INVENTION[0002]The gastrointestinal microbiota has been shown to play a number of vital roles in maintaining gastrointestinal tract functions and overall physiological health, playing a role in the control of bacterial overgrowth, bacterial translocation, nutrient availability, immune stimulation, septicemia as we...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/00A61K38/02A61K31/198A61K31/401A23K1/16A23K1/18A23L1/305A23L33/00A61K31/195
CPCA23K1/1631A61K31/401A23K1/1846A23L1/296A23L1/3051A23V2002/00A61K31/195A23K1/1634A61K31/198A23V2250/0642A23V2250/064A23V2250/0648A23V2250/0616A23V2250/0612A23V2250/16A23V2250/1578A23V2250/161A23V2250/1612A23V2250/1592A23V2250/1588A23V2250/1642A23V2250/06A23V2250/156A23V2250/702A23V2250/704A23V2250/641A23V2250/0644A23K20/147A23K20/142A23K50/40A23L33/40A23L33/175A61K9/0095
Inventor FAURE, MAGALIROCHAT, FLORENCEBREUILLE, DENISCORTHESY-THEULAZ, IRENE
Owner NESTEC SA
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