Pharmanutrient Composition(s) and System(s) for Individualized, Responsive Dosing Regimens

Abstract

Individualized responsive dosing pharmanutrient systems, compositions, methods of dosing, and processes of producing the same, which allow a consumer to generate individualistic biological responses / effects. More specifically, a pharmanutrient system for generating individualized biological conditions / responses which utilizes ultra-low dosage amounts of vitamins, minerals, amino acids, co-enzymes, organics substrates, inorganic or synthetic substrates, biological components, and / or other nutrients incorporated or provided with a pharmacologically active ingredient in a bio-active delivery system which preferably avoids first pass metabolism, such that an individual may take multiple doses of the same or different pharmanutrient based on varying desired biological response within each dosing period.

Description

RELATED APPLICATIONS[0001]This application is a continuation-in-part application claiming priority to pending non-provisional U.S. application Ser. No. 10 / 868,149, filed on Jun. 15, 2004, which further claims priority to pending provisional U.S. Application Ser. No. 60 / 561,097, filed on Apr. 8, 2004 each of which are incorporated by reference herein in their entirety.FIELD OF THE INVENTION[0002]The present technology relates generally to individualized, responsive dosing pharmanutrient products and / or systems, compositions, methods of treatment, and processes of producing the same, which allow a consumer to target identifiable, individualistic biological conditions or attendant responses thereto. More specifically, the present technology relates to a pharmanutrient product and / or system for targeting individualized biological conditions or attendant responses which utilizes ultra-low dosage amounts of vitamins, minerals, amino acids, co-enzymes, stimulants, and / or similar ingredient...

AI Technical Summary

Benefits of technology

[0016]Embodiments of the presently described technology provide one or more of the following advantageous features and / or objects:

[0019](3) Efficient rate of absorption into an animal or human body to improve bioavailability, biokinetics, and biodelivery;

[0022](6) A biological response equivalent pharmanutrient dosing unit that does not approach RDA or UL amounts, but is still effective in enhancing the overall well being of an individual and generating a biological response;

[0034]The one or more pharmanutrient compositions and / or systems are preferably separately configured to generate one or more pre-determined biological responses / effects / affects, including, but not limited to general metabolic system control and modulation, stress-relief, cellular metabolism, preventative or remedial anti-aging, hormonal release, improved cardiovascular outcomes (e.g., decreased hypertension and decreased atherosclerotic plaque deposition), energy conservation, modulated neurochemical release or uptake, energy utilization, glucose modulation, energy enhancement, cellular repair, enhanced memory, enhanced cognitive function, calmness, awareness, elimination or excretion of cellular or tissue by-products (e.g., ammonia), stimulation of the hypothalamic-pituitary-thyroid axis, fatigue relief, enhanced immune response modulation, antioxidation, liver detoxification, alcohol metabolism, modulation of tissue catabolic activity, syndrome metabolism modulation, fertility modulation, improved lymphatic system control, satiety modulation, weight modulation, oxygen metabolism modulation, pyruvate / lactic acid metabolism modulation, mitochondrial function modulation, and digestive enhancement.

Problems solved by technology

The intricate ways in which nutrients act on the body, however, are still far from clear.

Although standard and / or mega-dose regimens are a common practice for the prevention of disease, there is a great deal of debate in the literature and medical community regarding the efficacy of such regimens.

Moreover, consuming conventional large doses (i.e., standard or mega-dose) of vitamins, minerals, or other nutrients, in the absence of some deficiency and / or disease state, or without proper medical supervision, may cause harmful toxic effects and / or result in hypervitaminosis.

Additionally, a consumer usually has little choice in choosing the variety of ingredients, dosage levels, or dosing regimens of a conventional dietary supplement or pharmanutrient product.

Further, those same supplements may not adequately target an individual's specific dietary need or desired biological response at any given time.

Moreover, conventional dosage forms of dietary supplements, nutrients, and pharmanutrients typically only allow a consumer to take one or two doses per any given twenty-four (24) hour period.

As a result, conventional dietary supplements and pharmanutrients fail to recognize that the physiological state and resultant nutrient or pharmacologically active ingredient requirements of any single individual can depend upon and fluctuate based upon a number of different biophysical variables during the course of each day or dosing regimen period.

Thus, conventional “one size fits all” nutrient, pharmanutrient, and individual pharmacological active ingredient mega-dose dosage forms / regimens are not amenable to empirical, individualized dosage adjustment to achieve an individualized biophysiological objective or response for various biological conditions or events.

Another drawback with most conventional dietary supplements, nutrients, or pharmanutrient product / systems is that they suffer from poor degrees and / or rates at which the various nutrients or active ingredients contained therein are absorbed into the systemic circulation of the human or animal body and made available for biophysiological activity (e.g., “bioavailability”).

For example, it is believed by some within the medical and dietary supplement communities that one significant drawback to “mega-dosing” of vitamins, minerals, other nutrients or pharmacologically active ingredients / drugs is that increased dosages may not be adequately absorbed into the human or animal body, or may actually decrease absorption.

Thus, available transport mechanisms may become saturated and unable to absorb excess dose.

Additionally, another drawback to vitamin, mineral, or drug delivery via a conventional tablet or capsule is that differences in luminal pH along the gastrointestinal tract lining, surface area per luminal volume, blood perfusion, presence of bile and mucus, and the nature of epithelial membranes may prevent efficient absorption, activation, and the like of a nutrient or drug, thereby decreasing the bioavailability of each.

Additionally, as side effects are increased and / or the desired biological response, effect, or affect is decreased, individuals taking such conventional “mega-dose” supplements or pharmanutrients tend to become mal- or non-compliant.

However, aside from a delayed biophysiologic response as gastric emptying becomes rate-limiting, gastric irritability, and potential allergic reactions from the ingestion of such coating materials generally occur.

Further, enterically coated delayed release dosage forms must dissolve and typically be absorbed within a narrow time frame.

As a result, the human or animal body typically excretes the non-absorbed nutrient or drug rather than fully absorb and utilize either.

However, the compositions and methods of the Jang patent do not provide for ultra-low dosage amounts of vitamins or minerals, dosing flexibility, or a type of system, composition, or method for individualized, responsive dosing based on a desired and / or targeted biological response / effect / affect.

However, these patents do not utilize vitamins or minerals, and more specifically, ultra-low dosage amounts of nutrients which would operate to provide flexibility for individualized dosing alone, or in conjunction or concert with, or in combination with a drug.

Moreover, these products or processes do not provide a system or selection for varying the type or level of dosage depending on a biological response / effect / affect desired.