Composition for making pathological tissues dehydration and/or contraction

Abstract

The present invention provides a pharmaceutical composition for dehydrating and atrophying pathological tissues comprising ferric subsulfate, polyferric sulfate or a mixture thereof is disclosed. Ferric subsulfate and polyferric sulfate are traditionally used as water treatment agent. The inventor surprisingly discovered the medical value of these substances. The compositions are cost-effective, convenient to use and have significant effects in treatment of vascular diseases such as hemorrhoids, hemangiomas, hematomas (including hematomas caused by brain hemorrhage), thrombi and varices, and topical traumas such as bleeding and edemas. The compositions are also capable of killing various tumor cells by targeted injection.

Description

CROSS-REFERENCE TO RELATED APPLICATIONThe present application claims priority from Chinese patent application number 200810030331.4, entitled “PHARMACEUTICAL COMPOSITIONS FOR DEHYDRATING AND ATROPHYING PATHOLOGICAL TISSUES” and filed in the name of Kuok Leong TAM on Aug. 22, 2008. The entire content of the application is incorporated herein by reference.FIELD OF THE INVENTIONThe present invention relates to pharmaceutical compositions for dehydrating and atrophying pathological tissues.BACKGROUND OF THE INVENTIONFerric subsulfate, a compound having a molecular formula Fe4(OH)2(SO4)5, is a pale-yellow particle when it is in solid form. The particle is easily soluble in water to form a reddish-brown solution which can be crystallized and solidified at low temperature. The compound is obtained by reacting ferrous sulfate with heated dilute sulfuric acid and dilute nitric acid, and normally used as mordant or waste water treatment agent.Polyferric sulfate (PFS) is a polymer having a mol...

AI Technical Summary

Benefits of technology

Polyferric sulfate is a polymer of ferric subsulfate. Ferric subsulfate, polyferric sulfate or a mixture in any ratio thereof is capable of enabling pathological tissues to become dehydrated and necrotic, which are subsequently absorbed by, or form a scab and slough from normal tissues. The composition is effective in treatment of vascular diseases such as hemorrhoids, hemangiomas, hematomas, thrombi and varices, topical traumas such as bleeding and edemas, and tumors.

Preferably, the composition is a solid powder comprising as active component ferric subsulfate, polyferric sulfate or a mixture thereof in an amount of 10˜60% by weight, and balanced amount of solid excipient. Excipients are used to dilute the composition and can be selected from silicon dioxide and medical starch, etc. The powder can be applied on bleeding traumatic wounds or suppurative wounds, so that the wounds will form a scab and be cured in a short time.

The present invention is a use invention. Ferric subsulfate and polyferric sulfate are traditionally used as water treatment agent. The present inventor surprisingly discovered the medical value of these substances. A large amount of experiments were performed over years and demonstrated very good effect of the substances. These compositions are cost-effective, convenient to use and have significant effects in treatment of vascular diseases such as hemorrhoids, hemangiomas, hematomas (including hematomas caused by brain hemorrhage), thrombi and varices, and topical traumas such as bleeding and edemas. The compositions are also capable of killing various tumor cells by targeted injection.

Problems solved by technology

Of course, the concentration of the solution cannot be too high because the solution becomes saturated when the weight percent of the active component reaches about 45%.