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Method of Treatment or Prevention of Hair Loss or for the Enhancement of Hair Growth

a hair loss and hair growth technology, applied in the field of hair loss treatment or prevention or hair growth enhancement, can solve the problems of uncontrollable hair cycle, inability to easily pull out, anchorage of anagen hair, etc., and achieve the effect of enhancing hair growth or initiation of hair growth, and easy application to the skin

Inactive Publication Date: 2013-03-14
ADVANGEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a protein-based reagent that can be applied to the skin to prevent hair loss and promote hair growth. The reagent is a midkine family protein, such as midkine or pleiotrophin, that can be formulated as a topical formulation and applied to the skin. The reagent has been found to be effective in preventing hair loss and promoting hair growth in animals that are susceptible to hair loss or undergoing chemotherapy. The reagent can also be combined with other therapeutic agents or carriers for treatment of the same condition or for prevention of hair loss during therapy. The invention also provides a method for promoting or enhancing hair growth by administering the reagent to a subject in need.

Problems solved by technology

Anagen hairs are anchored deeply into the subcutaneous fat and cannot be pulled out easily.
For example, the hair cycle can become uncontrolled leading to accelerated hair loss, which may be temporary or permanent.
Alopecia caused by any of the foregoing factors is a source of low self-esteem and anxiety for many patients.
Those suffering from hair loss often experience embarrassment and fear being ridiculed by others because they look different.
In some subjects, alopecia may lead to depression.
Such treatment resulted in regrowth similar to that in the first treatment phase.
In cyclophosphamide-treated animals, follicles also progress to telogen rapidly, as evidenced by pink skin, and rapid loss of fur due to damage of the hair follicle.
None of these treatments is broadly applicable.
For example, such treatments may not prevent hair loss during treatment with a chemotherapeutic agent.
On the other hand, such compounds may produce undesirable side-effects.
Finasteride may also produce significant side-effects for some users, as a number of male users have reported erectile dysfunction, impotence, low libido, or gynecomestica after using that drug.

Method used

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  • Method of Treatment or Prevention of Hair Loss or for the Enhancement of Hair Growth
  • Method of Treatment or Prevention of Hair Loss or for the Enhancement of Hair Growth
  • Method of Treatment or Prevention of Hair Loss or for the Enhancement of Hair Growth

Examples

Experimental program
Comparison scheme
Effect test

example 1

Method for Producing Recombinant Midkine

[0132]A cDNA fragment comprising human MK open reading frame (nucleotide positions 1-432; SEQ ID NO: 4) was inserted into the yeast expression vector pPIC9 (Invitrogen). This recombinant plasmid was transfected into yeast (Pichia pastoris GS115; Research Corporation Technologies), and the desired clones were selected with histidine and G418.

[0133]Human MK protein secreted by yeast into the culture medium was purified by employing the following column chromatography in the order below:[0134]1. SP Steamlines (Pharmacia; adsorption and wash with 20 mM pH 5.5 acetate buffer, elution with 20 mM pH 3.5 acetate suffer containing NaCl);[0135]2. Sulfated Cellulofine (Seikagaku Kogyo, Japan; adsorption with 10 mM pH 7.2 phosphate buffer, wash with buffer containing 0.7 M NaCl, elution with buffer containing 2.0 M NaCl);[0136]3. Superdex 75 pg (Pharmacia; gel filtration with saline);[0137]4. Poly. Sulfoethyl A (Poly LC Co.; adsorption with 20 mM buffer c...

example 2

[0140]Hair-growing effects of external applications of midkine (MK) and pleiotrophin (PTN). 1 μg / ml of MK or PTN in 40% glycerol / phosphate buffered saline (PBS) (v / v) was prepared. 10 μl of the solution of MK or PTN was directly applied three times per week to alopecic regions of aged Black 6 mice (1.5 years old, MK heterozygous knockout (+ / −)). It was observed for 25 days after starting the application whether each of MK and PTN had a hair-growing effect. FIG. 1 shows the results of the observation. As clearly understood from FIG. 1 and the brief description thereof, application of MK or PTN promoted hair growth on the alopecic regions of the aged mice. In this experiment, the applications of MK and PTN stopped on Day 15, because the hair-growing effect of MK and PTN was already confirmed on Day 15. From Day 15 to Day 25, the amount of hair increased even though the applications of MK and PTN were stopped (FIG. 1). This shows that the hair-growing effects of MK and PTN last for som...

example 3

Hair-Growing Effects of Subcutaneous Injection of MK and PTN

[0141]1 μg / ml of MK or PTN in PBS was prepared. 50 μl of the solution of MK or PTN was injected subcutaneously into aged Black 6 mice (1.5 years old, MK homozygous knockout (− / −)). The subcutaneous injections of MK and PTN showed no hair-growing effect on Day 15 (FIG. 2) under these conditions in this animal model. After changing on Day 15 from the subcutaneous injection to external applications of MK or PTN in accordance with Example 2, the hair-growing effects of MK or PTN were observed on Day 25 (FIG. 2).

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Abstract

The present application relates to use of a Midkine family protein for growing hair on a mammal, or in the manufacture of a medicament for growing hair on a mammal, especially for treatment or prevention of different forms of alopecia.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of priority from Australian Application No. 2010900771 filed 24 Feb. 2010, the contents of which are incorporated in their entirety by reference.FIELD OF THE INVENTION[0002]The present application relates to the filed of therapy and prevention of hair loss or hair thinning in mammals, such as in humans suffering from or having a propensity to develop alopecia, and to the promotion of hair growth in mammals, such as in humans suffering from or having a propensity to develop alopecia.BACKGROUND TO THE INVENTIONHair and Hair Development[0003]Hair is integral to our body image and can have a profound influence on our self-esteem and self-confidence. The hair of non-human mammal species is commonly referred to as “fur”. Unless specifically stated otherwise, or the context requires otherwise, the term “hair” as used herein shall be taken to include “fur”. The term “hair” shall also be taken to include hair on ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/18A61K49/00A61P17/14
CPCA61K38/18A61K49/0008A61K2800/59A61Q7/00A61K49/0004A61K8/64A61P17/14G01N33/5008C07K14/435C07K16/18C07K16/22C07K16/24C07K16/28
Inventor SAKUMA, SADATOSHIHALASZ, MARIAJONES, DARREN
Owner ADVANGEN
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