Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Functional foods comprising diamine oxidase and uses thereof

a technology of diamine oxidase and functional foods, which is applied in the direction of drug compositions, peptide/protein ingredients, dispersed delivery, etc., can solve the problems of blocked nose, headache, and blocked nose of free histamine in the circulation, and achieves the effects of reducing the number of side effects

Inactive Publication Date: 2013-12-26
DR HEALTHCARE ESPANA
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention aims to provide functional foods that can prevent or treat diseases associated with high histamine levels in blood, such as migraines, chronic fatigue, fibromyalgia, spondylitis, and pain caused by muscle contractures.

Problems solved by technology

High concentrations of free histamine in the circulation trigger unwanted effects such as headaches, blocked-up nose or rhinorrhoea, respiratory tract obstructions, tachycardia, gastric and intestinal disorders, swelling of eyelids, skin rashes, low blood pressure, bronchospasm, etc.
An excess of histamine in the body due to lack of DAO, increases the risk of migraine.
The presence of these free amines in certain foods is considered to cause migraines.
However, functional foods comprising DAO to help prevent or treat diseases and conditions associated with high histamine levels in blood are not known.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Functional foods comprising diamine oxidase and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0057]Microgranules are prepared containing 4% of DAO, according to the following formula

DAO 4 mgManitol40 mgMicrocrystalline cellulose25 mgHydroxypropyl cellulose10 mgCorn starch10 mgCitric acid 6 mg

[0058]The microgranules are coated with hydroxypropyl methylcellulose.

example 2

[0059]The following skimmed milk suspension containing DAO is prepared:[0060]A. 10 g of microgranules containing 10% of DAO[0061]B. A dispersion of 2.5 g of gum arabic in 100 g of water and thoroughly hydrated[0062]C. 830 g of skimmed milk prepared with skimmed milk powder[0063]D. 0.15 g of kappa carrageenan

[0064]The pH of the final product is adjusted to 6.6 to 7.0, UHT sterilized and homogenised. The milk was stable showing no sedimentation during storage from 2° C. up to room temperature.

example 3

[0065]The following almond milk suspension containing DAO is prepared:[0066]A. 15 g of microgranules containing 10% of DAO[0067]B. A dispersion of 2.5 g of gum arabic in 100 g of water and thoroughly hydrated[0068]C. 830 g of almond milk made from almond milk powder[0069]D. 0.15 g of kappa carrageenan

[0070]The pH of the final product is adjusted to 6.6 to 7.0, UHT sterilized and homogenised. The milk was stable showing no sedimentation during storage from 2° C. up to room temperature.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
temperatureaaaaaaaaaa
weightaaaaaaaaaa
Login to View More

Abstract

The present invention relates to functional foods comprising DAO and their use for the prevention or treatment of diseases or pathological conditions associated with high levels of histamine in blood, in particular for the prevention or treatment of migraine, chronic fatigue, fibromyalgia, spondylitis and pain caused by muscle contractures.

Description

FIELD OF THE INVENTION[0001]The present invention relates to functional foods comprising diamine oxidase (DAO) for the treatment or prevention of diseases or pathological conditions associated with high histamine levels in blood, in particular for the treatment or prevention of migraine, chronic fatigue, fibromyalgia, spondylitis and pain caused by muscle contractures.BACKGROUND OF THE INVENTION[0002]Histamine [2(4-imidazolyl)-ethylamine] is an important mediator in many biological processes including inflammation, gastric acid secretion, neuromodulation and immune function regulation. Because of its potent pharmacological activity, even at very low concentrations, it is necessary to carefully regulate the synthesis, transport, storage, release and degradation of histamine to prevent undesirable reactions. High concentrations of free histamine in the circulation trigger unwanted effects such as headaches, blocked-up nose or rhinorrhoea, respiratory tract obstructions, tachycardia, g...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A23L1/305A61K38/44
CPCA23L1/3053A61K38/44A23L2/02A23L2/52A23V2002/00C12Y104/03022A61K9/0095A61K9/1623C12Y104/03006A23C9/1213A23C11/103A23C2210/40A23L33/115A23L33/17A23L33/18A61P21/02A61P25/06A61P25/32A61P43/00A23L11/65A23V2200/31A23V2200/3204A23V2250/032A23V2250/51084A23V2250/51086A23V2250/6418A23V2200/322A23V2250/161A23V2250/1882A23V2250/718C12N9/0004A23C9/13C12N9/00A61K9/0056
Inventor DUELO RIU, CARLOSDUELO RIU, JUAN JOSE
Owner DR HEALTHCARE ESPANA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com