Intrinsic raman spectroscopy

a raman spectroscopy and raman spectroscopy technology, applied in the field of raman spectroscopy, can solve the problems of substantial temporal changes in measured measurements and calibration errors, and achieve the effects of reducing errors, improving noninvasive analysis, and successful calibration transfer

Inactive Publication Date: 2016-04-14
MASSACHUSETTS INST OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The invention is about a method to correct for variations in the measurement of glucose levels in tissue using non-invasive techniques such as Raman spectroscopy. The method takes into account the time-dependent changes in the tissue and the volume of fluid in which the glucose molecules are dissolved. By measuring the ratio of two different optical signals, the method produces a corrected spectrum that removes distortions caused by the tissue properties and provides a more accurate measure of glucose concentration. This method can be used with different types of optical instruments and can improve the accuracy of non-invasive glucose analysis.

Problems solved by technology

The most significant cause of calibration error can be the substantial temporal changes in the measured Raman spectra that are observed.

Method used

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Embodiment Construction

[0042]Preferred embodiments of the present invention relate to the use of Raman spectroscopy for the measurement of blood analytes. Systems and methods used in conjunction with preferred embodiments include those described in U.S. Pat. No. 5,615,673 and in U.S. Applications PCT / US96 / 04136, 60 / 675,252 filed on Apr. 27, 2005, 60 / 701,839 filed on Jul. 22, 2005, 60 / 702,248 filed on Jul. 25, 2005, and Ser. No. 11 / 412,418 filed Apr. 27, 2006 this patent and these applications being incorporated by reference into the present application in their entirety.

[0043]FIG. 1 depicts the signal obtained from a human forearm as observed with a commercial Kaiser PhAT probe Raman system with 785 nm excitation. The background signal, after spectral correction for the combined response of the grating and the CCD. Each trace is obtained with a 1.5 minute collection time and the overall signal level is seen to decrease over the course of the nearly 2 hour measurement. The intensity decays across the spect...

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Abstract

The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the priority of U.S. Provisional Application No. 60 / 701,839 filed Jul. 22, 2005 and U.S. Provisional Application No. 60 / 735,986 filed Nov. 10, 2005 and U.S. application Ser. No. 11 / 492,214 filed Jul. 24, 2006. The entire contents of the above applications are being incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]The development of non-invasive systems and methods for the transcutaneous measurement of blood analytes, such as glucose, remain important for the diagnosis and treatment of a variety of conditions. Conventional blood sampling methods are painful and have other undesirable features. However, none of the non-invasive methods being developed has demonstrated sufficient accuracy or reproducibility for clinical use. A major obstacle in achieving reproducible optical measurement such as Raman spectroscopy is the variation in optical properties (absorption and scattering) from measurement site ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/1455A61B5/1495A61B5/145
CPCA61B5/1455A61B5/1495A61B5/14532A61B5/14546A61B2560/0223G01N21/65
Inventor BECHTEL, KATESHIH, WEI-CHUANFELD, MICHAEL
Owner MASSACHUSETTS INST OF TECH
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