56results about How to "Quantitative measurement" patented technology

The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.

A computer-implemented method and system for detecting possible occurrences of fraud in insurance claim data is disclosed. Historical claims data is obtained over a period of time for an insurance company. The fraud frequency rate and percentage loss rate for the insurance company are calculated. The fraud frequency rate and percentage loss rate for the insurance company are compared to insurance industry benchmarks for the fraud frequency rate and the percentage loss rate. Based on the comparison to the industry benchmarks, the computer system determines whether to perform predictive modeling analysis if the insurance company is within a first range of the benchmarks, to perform statistical analysis on the claim data if the insurance company is below the first range of the benchmarks or perform forensic analysis if the insurance company is above the first range of the benchmarks. Statistical analysis, predictive modeling or forensic analysis are then performed based on the benchmarks to determine possible occurrences of fraud within the insurance claim data.

The invention provides a method and device for monitoring human motion states. The method comprises the following steps which are repeatedly executed: acquiring an acceleration signal with set sampling duration from output of a three-axis acceleration sensor worn by a human body, and calculating energy and average power of the acceleration signal; judging the human body motion state according to the average power of the acceleration signal, if the average power is larger than a strenuous exercise threshold, then determining that the human body is in a strenuous exercise state, if the average power is smaller than the strenuous exercise threshold, then determining that the human body is in a sleeping state, if the average power is smaller than the strenuous exercise threshold and larger than a sleeping threshold, then determining that the human body is in a slight exercise state; if the human body is in the strenuous exercise state, then judging whether the acceleration signal has psuedo-periodicity, if not, determining that the human body is in an irregular strenuous exercise state, and if yes, determining that the human body is in a regular strenuous exercise state. According to the method and device for monitoring human motion states, various motion states of people can be automatically and precisely monitored in an all weather mode.

Disclosed is a microarray chip for allergy-related immunoglobulin detection, especially for quantitative detection of total IgE and allergen-specific immunoglobulins (such as specific IgE, specific IgG, and specific IgM), which comprises a solid substrate, a reactive layer fabricated on the solid substrate, and at least one allergen or substance capable of binding to immunoglobulin of interest. Whereby, use the result of quantitative detection for allergen-specific IgE to determine hypersensitivity level. In addition, a method for allergy-related immunoglobulin detection using the microarray chip is present, which uses a secondary monoclonal antibody to minimize non-specific binding and applies an enzymatic reaction to amplify reaction signal. An efficient way is thus obtained, which not only reduces time consumption but also provides quantitative measurement.

The present invention provides a method to firmly attach any polypeptide to a gold surface regardless of its intrinsic gold-binding properties. The method describes the production of recombinant fusion proteins consisting of polypeptides of interest and a high affinity gold binding peptide consisting of 1 to 7 repeats of a unique amino acid sequence. By this method, many biologically active polypeptides lacking intrinsic gold-binding properties can be firmly attached to gold surfaces. The disclosure includes evidence that fusion proteins containing the gold-binding sequences provide superior stability and activity compared to similar molecules lacking the tag when used to construct biosensors. The invention provides a method that is a significant improvement over existing chemical and physical adsorption protocols to attach polypeptides to gold and, therefore, can provide benefits to many applications utilizing gold.

The interactive credential system and method has a database containing employee-employer-applicant surveyed information, industry specific criteria, such as insurance loss history and account performance, an authorization code for authorizing access to the database and a control device, operatively associated with the database, for presenting weighted scores. The system further includes a surveyed party processor operatively associated with the control device, and wherein the surveyed party processor is capable of transmitting the authorization code to view the surveyed information. The system also has a participant processor that is capable of requesting authorization to download the employee-employer-applicant information, including weighted scores computed from the system's algorithms processed from industry specific parameters.

An optical apparatus and method comprising a light source, an array detector for area imaging and an optical cell assembly. The optical cell assembly comprises a chamber which is arranged to receive a sample of a material including an analyte, a fluid inlet and a fluid outlet coupled to the chamber. A fluid dissolution medium stream passes through the chamber such that the sample can dissolve into the dissolution medium. The chamber is in at least one light path created between the light source and the array detector. The array detector comprises a two dimensional array of detector locations arranged to provide an output signal indicative of the light absorbance of the analyte within the chamber such that the output of the array detector is indicative of the concentration profile of the analyte near the surface of the sample.

The invention discloses a detection system of an automatic flexible checking tool based on a contact measuring head, which comprises an adjustable tool, a measuring head seat, the contact measuring head, a controller, software and a main control computer, wherein the system uses the adjustable flexible tool to fix a workpiece and uses a contact measuring head with a communication interface to measure a relative dimension error. The measuring head is mounted on the measuring head seat capable of freely adjusting the gesture of the measuring head. Through the controller, one or more measuring heads are connected with the main control computer which controls the collection and treatment of measured data and realizes the automatic detection of the workpiece error. The system software makes statistic of the measured data, provides the information needed for controlling a statistic process and realizes the self-adapting calibration of the system. The invention has the advantages of good adjustability, low cost, high precision, fast speed, full automation, measures of quantization and the like, is an effective alternative scheme of current manual visual mechanical checking tool, and is also an excellent on-line detection scheme for dimension error of mechanical products.

Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.

A sensor for monitoring a physiological function such as hydration including microelectrode arrays and electronics operatively connected and placed on an elastic strip, the assembled sensor being attached to a person in such a manner as to pinch and raise the skin under the elastic strip.

Techniques disclosed herein include methods for creating a directed self-assembly tunable neutral layer that works with multiple different block copolymer materials. Techniques herein can include depositing a neutral layer and then post-processing this neutral layer to tune its characteristics so that the neutral layer is compatible with a particular block copolymer scheme or schemes. Post-processing herein of such a neutral layer can modify a ratio of pi and sigma bonds in a given carbon film or other film to approximate a given self-assembly film that will be deposited on this neutral layer. Accordingly, a generic or single material can be used for a neutral layer and modified to match a given block copolymer to be deposited.

A predictive choice process of a manufacturing process of an optical component intended to be subjected to laser fluxes, the choice being intended to select from among several possible manufacturing processes that which results in components having better laser flux behaviour than those obtained by the other possible processes characterised in that a) a number N of cathodoluminescence measurements are made on components obtained by a first of the possible manufacturing processes, while the component receives an electronic beam having a determined energy, a focus on the surface of the determined component and a determined intensity controlled by a value of a ground current measured on the component, while it is being subjected to said electronic beam, b) an average cathodoluminescence value on the N measurements is calculated, c) operations a) and b) on components obtained by each of the other possible manufacturing processes are repeated, d) the most advantageous manufacturing process is decided as the one for which the average cathodoluminescence value is the lowest.

Described are methods allowing measurement of adsorption and desorption of analytes with membranes or resins directly using surface plasmon resonance (SPR). Also described are methods for assembling intact resins or membranes on SPR surfaces. Such methods provide estimates of mass-action ion-exchange adsorption and desorption rates accounting for steric (σ) and characteristic charge (ν) effects. The methods further permit accurate estimation of rate constants for uniform adsorption of a homogeneous analyte solution on homogeneous adsorptive sites distributed heterogeneously in space, relative to the planar boundary. Solutions are obtained for locally porous media and solid spheres. The methods are extendible to other media and heterogeneous adsorptive sites. The methods further provide for enhancement of lateral mass transport in such optical measurement instruments through radial hydrodynamic diffusion (radial dispersion) by, for example, incorporating porous media in flow cells of detection devices such as, but not limited to, SPR or TIRF instruments.

A thermometric temperature apportionment method which is provided with a window-opening correction function relates to a thermometric temperature apportionment method. The invention solves the problem that the existing heat quantity apportionment system of temperature method can not distinguish the window-opening in real time and the time of distinguishing is delayed, the heat quantity consumed by opening window can not be measured quantificationally, and the punishment system for window-opening can not be quantified. The main steps of the method of the invention is that the heating load of each family in building in apportionment measuring in a unit time is delta Qik = delta Qtik + delta Qwik, room temperature measured heat quantity of each family delta Qtik in unit time is calculated, additional heat quantity delta QWik of window-opening of each family in unit time is calculated, and the heating load in apportionment measuring of each family is evaluated. The invention solves the quantificational calculation problem of energy consumption generated by opening window in theory, provides theory support for the temperature apportionment technology, and realizes distinguishing in real time for window-opening in temperature heat quantity apportionment method. Further, the invention can quantificationally calculate the heat quantity consumed by opening window, quantify the punishment system for window-opening, and solves justice problem.

The present invention relates to a rapid detection method and a rapid detection apparatus of an all-vanadium flow battery positive electrode side reaction. The method comprises: acquiring the first discharging curve of an all-vanadium flow battery positive electrode electrolyte under preset parameters; acquiring the second discharging curve of the all-vanadium flow battery positive electrode electrolyte under preset parameters; according to the first discharging curve and the second discharging curve, determining the transmitted light intensity difference corresponding to the all-vanadium flow battery positive electrode side reaction; and determining the proportion of the all-vanadium flow battery positive electrode side reaction under the current parameter. With the method and the apparatus of the present invention, the proportion of the positive electrode side reaction of the vanadium battery under different parameters can be rapidly measured, the optimal vanadium battery parameter can be determined, and the basis is established for the determination of the parameters of the large-batch vanadium batteries in the industrial production.

The invention discloses a method to measure high pressure buffer jar slurry outlet flow. The slurry flow would be calculated according to the height of liquid. When the liquid location is lower than baffle, the flow could be calculated by liquid height and openness of water gate. When liquid location is higher than baffle, the flow under baffle could be calculated according to water gate, and the flow over baffle could be calculated according to measuring weir discharge-measurement method. The invention could test slurry outlet flow and is convenient to use.

A device used for measuring performance parameters of power amplifier consists of function operation module for carrying out operation according to preset function, mutual correlator module for carrying out mutual correlation operation on output signal, nonlinear output module for carrying out normalization treatment on mode maximum value of output signal, self-correlator module for carrying out self-correlation calculation on output signal, memory length output module for carrying out judgment on output signal and for outputting memory length signal.

Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.

The invention discloses a rainfall infiltration demonstration device and method for laterally adjacent anisotropic unsaturated soil. The device comprises an adjustable rainfall simulation structure for providing rainfall of different intensities, a loading box for loading soil samples and a rainwater collection and measurement structure communicated with the loading box through a pipeline; a detachable partition plate for lateral loading of the soil samples with different permeability properties is arranged in the loading box. The device disclosed by the invention is simple in structure and convenient to use; through the device, not only can an infiltration path of rainwater inside the unsaturated soil be clearly observed, but also the water infiltration amount of the unsaturated soil canbe quantitatively determined.

Described are apparatus and methods allowing measurement of adsorption and desorption of analytes with membranes or resins directly using increased lateral mass transport. Such increased lateral mass transport may be accomplished through the incorporation of a porous media, such as a fibrous bed or a concentrated bed of spheres, into said flow cell. Further described is a method of determining if a flow cell would benefit from increased lateral mass transport comprising comparing the rate of surface reaction to the mass transfer coefficient for a given analyte. The detection method for the measurement of adsorption and desorption of analytes may be based on the evanescent wave phenomenon at total internal reflection, such as surface plasmon resonance (SPR), critical angle refractometry, total internal reflection fluorescence (TIRF), total internal reflection phosphorescence, total internal reflection light scattering, optical waveguide fluorescence, evanescent wave. ellipsometry, nuclear magnetic resonance (NMR) spectroscopy, quartz crystal microbalance / dissipation, calorimetry, ellipsometry, and voltammetry.

This invention relates to a method for measuring autophagy in cells, comprising using, as a probe reagent, a single fluorescent protein, to measure a change in fluorescence properties of the fluorescent probe reagent depending on pH changes associated with autophagy, thereby determining the presence or activity of autophagy, wherein the single fluorescent protein is resistant to degrading enzyme activity in the lysosome or vacuole of the cell, it is not denatured or inactivated under acidic to neutral pH environment, and it is capable of changing excitation spectra or fluorescence spectra when located under the environments of acidic region and neutral region.

The invention discloses a fluorescence detection agent for a p53 protein. The fluorescence detection agent comprises a magnetic nano-particle, double-stranded DNA, and a functional layer coating the surface of the magnetic nano-particle and connected with the double-stranded DNA; the double-stranded DNA is obtained through hybridizing DNA-1 single strand and DNA-2 single strand; the DNA-1 is a carboxyl oligonucleotide probe, and the sequence is COOH-(CH2)6-TTT TTT TCC GGG CAT GCC CGG CAT TGC-3'; and the DNA-2 is the partial complementary sequence of the DNA-1, and the sequence is 5'-GGG CAT GCC C-3'. The invention also discloses a preparation method of the fluorescence detection agent, and an application of the fluorescence detection agent in the detection of the wild p53 protein. The agent has the advantages of low preparation cost, realization of sensitive, rapid and accurate capture of the p53 protein, realization of ultra-sensitive, highly- selective and highly-accurate detection of the p53 protein, low detection limit, and realization of quantitative analysis and detection of the p53 protein in normal cells and cancer cell lysate, and can be used in clinical diagnosis and early detection of cancers.

A method for quantifying infectious particles of a virus in a sample comprises providing a layer of host cells of the virus, contacting the layer of host cells with a preparation of the sample, and culturing the cells under conditions wherein the cells are submerged in a thin layer of liquid culture medium, and wherein the virus infects host cells and releases its progeny from said infected host cells, imposing a flow of the liquid medium, wherein the spread of the viral progeny to uninfected host cells is enhanced, culturing the cells under conditions to allow further virus infection and viral gene expression, wherein infected host cells develop an observable indication of viral gene expression, and determining the number of infected host cells, whereby the number of infectious particles of the virus in the sample is quantified. The method may be used for measuring viral growth rate or for screening for antiviral compounds. Also provided are microfluidic devices suitable for the inventive method.

The embodiment of the invention relates to the technical field of aerostats, and provides an aerostat valve air tightness detection system and detection method. The detection system comprises a gas supply device, a test tank, and a gas volume measurement device. A valve to be tested is installed in the test tank to divide the interior of the test tank into a high-pressure cavity and a low-pressurecavity. The high-pressure cavity is provided with a first air inlet, and the air supply device is communicated with the first air inlet. The air supply device is used for supplying air to the high-pressure cavity and keeping the high-pressure cavity in a constant pressure state. The low-pressure cavity is provided with an air outlet, and the gas volume measuring device is communicated with the air outlet. According to the aerostat valve air tightness detection system provided by the embodiment of the invention, the detection of the air tightness of an aerostat valve is realized, and the gas leakage amount of the aerostat valve in a specific pressure environment can be quantitatively and accurately measured.

The invention discloses a device for testing the cotton content of a cotton boll shell. The device comprises a seed cotton extracting device, a three-dimensional force measuring device, a cotton boll shell angle adjusting device and a control device, wherein the seed cotton extracting device comprises a seed cotton chuck and a seed cotton extracting driving device; the three-dimensional force measuring device comprises a cotton boll clamp and a three-dimensional force sensor; the cotton boll shell angle adjusting device comprises an angle adjusting plate and an angle adjusting frame; and the control device is in communication connection with the seed cotton extracting device and the three-dimensional force measuring device so as to regulate and control the seed cotton extracting angle and speed of the seed cotton chuck. The device provided by the invention can measure the size of the cotton boll shell flocculability of different varieties from two parameters of seed cotton extraction angle and speed, provides reference for cotton genetic breeding in the aspect of flocculability, and enables agronomic characters to be matched with cotton picking machinery to the greatest extent, thereby greatly improving the complete picking rate of mechanical picking. The invention further provides a cotton boll shell flocculability testing method based on the cotton boll shell flocculability testing device.

The invention relates to a grape deterioration monitoring instrument based on LMSE, wherein the grape deterioration monitoring instrument is a low-cost and small-size grape deterioration monitoring instrument, and can real-timely and quantitatively measure the CO2 content and the ethanol content in volatile substances of grapes. The grape deterioration monitoring instrument based on LMSE comprises a gas sensor constant voltage circuit, a current-voltage conversion, a microcontroller, a power supply circuit and an interface and alarm unit, and the structure is characterized in that the gas sensor constant voltage circuit is provided with an ethanol gas sensor constant voltage circuit and a CO2 sensor module, the CO2 sensor module and an ethanol sensor conditioning circuit are connected to the input terminal of the microcontroller, the current-voltage conversion is arranged inside the microcontroller, the output terminal of the microcontroller is connected to the interface and alarm unit, the interface and alarm unit comprises RS232, a liquid crystal display module and a sound and light alarm module, and the power supply circuit comprises a battery pack and a 3.3 V automatic voltage booster circuit.

Techniques disclosed herein include methods for creating a directed self-assembly tunable neutral layer that works with multiple different block copolymer materials. Techniques herein can include depositing a neutral layer and then post-processing this neutral layer to tune its characteristics so that the neutral layer is compatible with a particular block copolymer scheme or schemes. Post-processing herein of such a neutral layer can modify a ratio of pi and sigma bonds in a given carbon film or other film to approximate a given self-assembly film that will be deposited on this neutral layer. Accordingly, a generic or single material can be used for a neutral layer and modified to match a given block copolymer to be deposited.