Fluorochemical targeted therapies
a fluorochemical and targeted therapy technology, applied in the field of compositions and methods, can solve the problems of affecting the effectiveness of gas-based therapies for internal ailments, unable to effectively exploit the methods of exploiting the benefits of gas-based therapies, and cells that thrive in microenvironments lacking oxygen,
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Benefits of technology
Problems solved by technology
Method used
Image
Examples
example 1
of Cancer Cells
[0132]The Ability of Fluorocarbons to Dissolve and Carry Large Amounts of Gaseous substances makes them a novel anti-cancer therapeutic that may alter the cancer-promoting environment to be less habitable for pre-cancer and cancer cells. To analyze the effectiveness of the combination of fluorocarbons and gaseous substances as an anti-cancer therapeutic, the growth of cancer cells was measured in the presence of fluorocarbon with normal environment (Normoxia) or fluorocarbon with carbon dioxide (Hypoxia).
[0133]In particular, two human pancreatic cancer cell lines (Pan02 and Capan2) and one immortalized human pancreatic stellate cell line were cultured by methods known in the art. Briefly, cells were plated to 30% confluence and then perflubron / Egg Yolk Phospholipid emulsion (5.8 mg Perflubron / mL) was added to culture wells in triplicate at dilutions of 1:10, 1:20, 1:40, 1:80, 1:160, 1:320, 1:640, and 1:1280. Following administration of perflubron, samples were either ...
example 2
erapy
[0134]A subject with a cancerous mass will undergo a pre-treatment CT / PET scan with fludeoxyglucose (FDG) and fluoromisonidazole (FMISO), a tumor hypoxia agent, to establish a baseline. This scan will also identify the volume and location of the hypoxic areas of the cancer mass. Next, at least one needle catheter will be inserted into the tumor and intratumoral pressure will be obtained. If a high intratumoral pressure is observed, a slow instillation of collagenase over 10 minutes could be considered to reduce the pressure (e.g. 30-40%). At this time, intravenous administration of a perfluorocarbon emulsion, chemortherapeutics, radiation agents, or a combination thereof, could be performed to utilize tumor vessels. Since the tumor pressure is lowered by the collagenase, this may enable a higher percent of drug delivery into the tumor.
[0135]Once a maximal amount of the intravenous medicine is in the tumor (e.g. ˜4 hours), a slow injection with or without a convection pump of th...
example 3
[0136]A patient with metastatic colon cancer exhibiting peritoneal studding and greater than 1 liter of ascites fluid will be treated using the following protocol. Before treatment, a pre-treatment PET / CT FMISO, FDG and MRI including F-19 will be performed to ascertain the status of the cancer. Laprascopic insertion of a scope will be used to remove the bulk of the ascites and concurrently a collagenase could be injected intraveneously to reduce intratumoral pressure. A 60% perflubron emulsion mixed with the maximum soluble and tolerated amount of 2DG, and possibly collagenase, will be instilled to cover / submerge all of the peritoneal surface metastasis. The combination emulsion is then allowed to mix with the CO2 gas of the laprascopic procedure. The abdomen will be supported with the combination for 2 hours. Approximately 4-24 hours post-op, the gas will be changed to O2 by having the patient breathe supplemental or hyperbaric O2. Chemotherapeutics and loca...
PUM
| Property | Measurement | Unit |
|---|---|---|
| temperature | aaaaa | aaaaa |
| wavelength | aaaaa | aaaaa |
| weight-to-weight ratios | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More