Method for enhancing expression of moisturizing-related substance in epidermis

Pending Publication Date: 2022-03-03
J NETWORK
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Benefits of technology

[0013]Preferably, the diacylglycerol PEG adduct is one of the ingredients of cosmetics or pharmaceuticals, and the method for enhancing expression of a moisturizing-related substance in an epidermis further comprises applying the cosmetics or pha

Problems solved by technology

However, the action of the diacylglycerol PEG adduct in

Method used

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  • Method for enhancing expression of moisturizing-related substance in epidermis
  • Method for enhancing expression of moisturizing-related substance in epidermis
  • Method for enhancing expression of moisturizing-related substance in epidermis

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[0034]Embodiments of the present invention are described below with reference to the drawings.

[0035]The present invention has been made by taking advantage of a newly found property of a diacylglycerol polyethylene glycol adduct (diacylglycerol PEG adduct). The newly found property is an action of enhancing expression of a moisturizing-related substance in a human epidermis.

[0036]A structural formula of a diacylglycerol PEG adduct, which is a lipid molecule according to the present invention, is schematically represented in Chemical formula 2.

[0037]A diacylglycerol PEG adduct is composed of a glycerol skeletal part (CH2CHCH2) having three carbons, a PEG chain that is linear polyethylene glycol bonded to one terminal carbon of the three carbons in the skeletal part, and long-chain fatty acids (COOR) of the same type respectively bonded to the other two carbons of the three carbons. The PEG chain part is hydrophilic and the long-chain fatty acid parts are hydrophobic.

[0038]In the foll...

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Abstract

To enhance expression of a moisturizing-related substance in an epidermis by using a diacylglycerol PEG adduct, a method for enhancing expression of a moisturizing-related substance in an epidermis is provided which includes applying a diacylglycerol PEG adduct to the epidermis as an active ingredient. The moisturizing-related substance is filaggrin, profilaggrin, and/or caspase-14. The diacylglycerol PEG adduct is selected from a group consisting of PEG-12 glycerol dimyristate (GDM12), PEG-12 glycerol distearate (GDS12), PEG-23 glycerol distearate (GDS23), PEG-23 glycerol dipalmitate (GDP23), and PEG-12 glycerol dioleate (GD012).

Description

CROSS-REFERENCE TO RELATED APPLICATIONS AND CLAIM TO PRIORITY[0001]This application is related to application no. 2020-146116, filed Aug. 31, 2020 in Japan, the disclosure of which is incorporated herein by reference and to which priority is claimed.FIELD OF THE INVENTION[0002]The present invention relates to a method for enhancing expression of a moisturizing-related substance in an epidermis.BACKGROUND OF THE INVENTION[0003]Vesicles composed of a phospholipid and a surfactant are known and are also referred to as liposomes. Japanese Patent No. 4497765 presents a preparation method for causing spontaneous formation of vesicles by using a lipid mainly containing a diacylglycerol polyethylene glycol adduct (hereinafter, also called “diacylglycerol PEG adduct”) in place of a phospholipid and mixing it with water or a surfactant . Such vesicles are used in a drug delivery system that delivers a target substance, for example, a protein or an antibody, to cells in a living organism by en...

Claims

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Application Information

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IPC IPC(8): A61K47/60A61K47/62A61K47/69
CPCA61K47/60A61K47/6903A61K47/62A61K8/86A61Q19/00A61K31/77A61P17/00A61Q19/08A61Q19/007
Inventor MIYOSHI, TATSUROKELLER, BRIAN CHARLESKODAMA, AKIRA
Owner J NETWORK
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