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Method for enhancing expression of moisturizing-related substance in epidermis

Pending Publication Date: 2022-03-03
J NETWORK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The present invention provides a new way to enhance the expression of moisturizing substances in the epidermis. This is done by using a specific ingredient called diacylglycerol PEG adduct. By applying this ingredient to the epidermis, it can help to increase the amount of moisturizing substances produced and released there. This can provide a more effective way to moisturize the skin and improve its appearance.

Problems solved by technology

However, the action of the diacylglycerol PEG adduct in the living organism is still unclear in many respects.

Method used

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  • Method for enhancing expression of moisturizing-related substance in epidermis
  • Method for enhancing expression of moisturizing-related substance in epidermis
  • Method for enhancing expression of moisturizing-related substance in epidermis

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Embodiment Construction

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[0034]Embodiments of the present invention are described below with reference to the drawings.

[0035]The present invention has been made by taking advantage of a newly found property of a diacylglycerol polyethylene glycol adduct (diacylglycerol PEG adduct). The newly found property is an action of enhancing expression of a moisturizing-related substance in a human epidermis.

[0036]A structural formula of a diacylglycerol PEG adduct, which is a lipid molecule according to the present invention, is schematically represented in Chemical formula 2.

[0037]A diacylglycerol PEG adduct is composed of a glycerol skeletal part (CH2CHCH2) having three carbons, a PEG chain that is linear polyethylene glycol bonded to one terminal carbon of the three carbons in the skeletal part, and long-chain fatty acids (COOR) of the same type respectively bonded to the other two carbons of the three carbons. The PEG chain part is hydrophilic and the long-chain fatty acid parts are hydrophobic.

[0038]In the fol...

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Abstract

To enhance expression of a moisturizing-related substance in an epidermis by using a diacylglycerol PEG adduct, a method for enhancing expression of a moisturizing-related substance in an epidermis is provided which includes applying a diacylglycerol PEG adduct to the epidermis as an active ingredient. The moisturizing-related substance is filaggrin, profilaggrin, and / or caspase-14. The diacylglycerol PEG adduct is selected from a group consisting of PEG-12 glycerol dimyristate (GDM12), PEG-12 glycerol distearate (GDS12), PEG-23 glycerol distearate (GDS23), PEG-23 glycerol dipalmitate (GDP23), and PEG-12 glycerol dioleate (GD012).

Description

CROSS-REFERENCE TO RELATED APPLICATIONS AND CLAIM TO PRIORITY[0001]This application is related to application no. 2020-146116, filed Aug. 31, 2020 in Japan, the disclosure of which is incorporated herein by reference and to which priority is claimed.FIELD OF THE INVENTION[0002]The present invention relates to a method for enhancing expression of a moisturizing-related substance in an epidermis.BACKGROUND OF THE INVENTION[0003]Vesicles composed of a phospholipid and a surfactant are known and are also referred to as liposomes. Japanese Patent No. 4497765 presents a preparation method for causing spontaneous formation of vesicles by using a lipid mainly containing a diacylglycerol polyethylene glycol adduct (hereinafter, also called “diacylglycerol PEG adduct”) in place of a phospholipid and mixing it with water or a surfactant . Such vesicles are used in a drug delivery system that delivers a target substance, for example, a protein or an antibody, to cells in a living organism by en...

Claims

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Application Information

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IPC IPC(8): A61K47/60A61K47/62A61K47/69
CPCA61K47/60A61K47/6903A61K47/62A61K8/86A61Q19/00A61K31/77A61P17/00A61Q19/08A61Q19/007
Inventor MIYOSHI, TATSUROKELLER, BRIAN CHARLESKODAMA, AKIRA
Owner J NETWORK
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