3 results about "Ionic calcium" patented technology

The invention discloses a preparation method of hydrogel loaded with a peptide calcium chelate, and belongs to the field of biological materials. The hydrogel loaded with the peptide calcium chelate prepared by the invention solves the key problems of poor stability, low bioavailability and the like of the current peptide calcium chelate in a gastrointestinal tract environment, and provides an innovative solution for improving the calcium absorption promoting efficiency of the peptide calcium chelate. The hydrogel loaded with the peptide calcium chelate prepared by the invention solves the potential adverse effects of gastrointestinal tract stimulation, calculus risk increase, competitive absorption with other trace elements and the like possibly caused by an ionized calcium supplement in a body. Compared with the inherent defects of poor water solubility, easiness in precipitation, low absorptivity and the like generally existing in the traditional calcium supplement, the hydrogel realizes slow and controllable release of the calcium element by virtue of a unique three-dimensional network structure, and provides a safer, more efficient and milder new calcium supplement scheme for an organism.

The present invention relates to a composition for use in formulae for infants or young children comprising partially hydrolysed protein, ionic calcium and an oil mix comprising palmitic acid esterified to triacylglycerols wherein the palmitic acids esterified in the sn-2 position of triacylglycerols in an amount of at least 20% by weight of total palmitic acid. Furthermore, the invention relates to an infant formula comprising said composition and the use of said composition or infant formula.

Provided are a hydrogel microsphere for constructing a bone organoid, a kit, a bone organoid, a bone organoid-loaded hydrogel, and a preparation method therefor and the use thereof. The kit comprises (1) a gel system and / or (2) a culture medium system, and further comprises (3) a phosphorus source and / or a calcium source, wherein an addition amount of the phosphorus source in the gel system or culture medium system is 24000-33000 mg / L; and an addition amount of the calcium source in the culture medium system is 2-8 mmol / L. The calcium source and the phosphorus source required for mineralization are introduced into a hydrogel and a culture matrix during the in vitro culture of bone organoids. Without external assistance, only a single cell type is used, along with simple ionic calcium and phosphorus, and microspheres are used to regulate the spatial distribution of calcium and phosphorus, which is beneficial to promoting cellular mineralization and osteogenesis. The in-situ mineralization method can effectively guide osteogenesis, mineralization, cell layer formation, shaping and remodeling, promote the development of bone organoids, effectively shorten the bone repair cycle, and achieve greater safety and broader applicability.