The invention relates to a
small RNA /
DNA whitening product series, which mainly consists of a
small RNA skin whitening
lotion and a
small RNA skin beauty cream. The small
RNA skin whitening
lotion mainly comprises efficient active ingredients for removing skin pigmentation and whitening skin, such as nano single-strand or double-strand oligonucleotides for specially and efficiency restraining genes (Asip, Mclr, Mitf, Dct, Silv, Oca2, Myo5a, Loc51151, Rab27a, Pomc, OA1,F2rl1,
Kinesin, Slc24a5, Tyr and Tyrp1) relevant to
melanin generation and a transdermal agent for stimulating oligonucleotides to enter skin melanocytes; the small
RNA skin beauty cream comprises a plurality of highly active materials for maintaining pure and white skin and small
RNA segments to prevent the sunshine from damaging the protective components of the skin and remove free radicals, and anti-aging and anti-inflammatory effective molecules. In addition, the invention further provides a formulation, a method and a procedure for preparing the series of whitening products.