The invention discloses a tumor cell membrane coated nanometer material, a method for preparing the same and application of the tumor cell membrane coated nanometer material, and belongs to the fieldof nanometer materials. The tumor cell membrane coated nanometer material is particularly a tumor site targeting bionic nanometer material. Cancer cell membranes are coated on the surfaces of mesoporous silicon dioxide nanometer particles (MSN), and glucose oxidase (GOx) is loaded on the MSN, so that hunger treatment can be carried out. The tumor cell membrane coated nanometer material, the methodand the application have the advantages that the surfaces of bionic materials are functionalized, CMSN-GOx has immune escape and homologous targeting capability, and accordingly enrichment of nanometer particles on tumor sites can be obviously improved; tumor can be partially ablated by the prepared CMSN-GOx nanometer particles, and certain antitumor immune response can be generated by means of tumor membrane induction; the tumor can be effectively ablated by the aid of hunger therapy by the CMSN-GOx combined with PD-1 immunotherapy as compared with injection of only PD-1 immunosupressant orthe CMSN-GOx, and adaptive immune response can be induced; the tumor cell membrane coated nanometer material is excellent in biocompatibility and has great clinical application potential.