The invention belongs to the field of daily chemical products and relates to an anti-acne moisturizing cream and a preparation method thereof. The anti-acne moisturizing cream is prepared from the following raw materials: glycerol, squalane, hyaluronic acid, tea tree essential oil, deep sea roe extract, deep sea water, macadamia nut oil, spermaceti, hydrolysate, traditional Chinese medicine extract and sterile water; the traditional Chinese medicine extract is prepared from the following crude drugs: panax notoginseng saponins, moutan bark, cicada slough, blue gum, rhizoma bletillae, radix scrophulariae, witch hazel, chamomile, plum, peach blossom, seed of Chinese waxgourd, ginkgo and aloe. The effective components of the anti-acne moisturizing cream provided by the invention can rapidly permeate through folliculus pili, and the anti-acne moisturizing cream is capable of effectively regulating skin sebum balance, sterilizing skin and diminishing inflammation, removing toxic materials and stasis, relieving pain and expelling pus, clearing turbidity and expelling toxin, promoting face skin metabolism, removing acnes, repairing damaged skin, calming and easing the face skins and refining large pores to enable the skins to be glossy, fine and smooth; while the acnes are effectively removed, scars or acne marks cannot be left on the face skins.