Marine bacteria strain for producing prodigiosin and the method for producing prodigiosin

Abstract

The invention provides a marine bacterial strain screening from the marine bacteria which can produce prodigiosin and a method for fermentation production of prodigiosin by using the said strain. The said marine bacterial strain is Pseudomonas sp.105001 CCTCC M 205164. The red metabolite of the said strain - the prodigiosin compound of the invented product can be prepared by selecting Pseudomonas sp.105001 CCTCC M 205164 as production strain, preparing mother seeds, by fermentation culture and extracting red metabolite and purifying metabolite. The new marine bacterial strain provided by this invention is of stable heredity and quick reproduction, which can perform large scale fermentation production and the prodigiosin production using the said marine bacteria, opens a new approach for study and exploitation of marine microbial resource.

Description

technical field

[0001] The invention relates to a marine bacterial strain capable of producing prodigiosin screened from marine bacteria and a method for fermenting and producing prodigiosin with the bacterial strain. Background technique

[0002] Prodigiosin, with a unique structure and a pyrrole pyrromethene skeleton, was previously mainly derived from the clinical pathogenic microorganism Serratia marcesens. Prodigiosin compounds are a general term for compounds with pyrrole pyrromethene structure characteristics. There may be 2, 3 or 4 pyrrole rings in the entire molecule, and the pyrrole rings may be connected with long chain alkyl groups or other functional groups. Prodigiosin has a variety of significant pharmacological activities: 1) anti-tumor activity; 2) anti-microbial activity; 3) anti-malarial; 4) promotion of cell apoptosis; 5) strong immunosuppressive activity, its immune mechanism and It is related to its unique pyrrole pyrromethene skeleton structure. Due ...

Images