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Curcuma zedoary oil controlled release elution rack for preventing and curing re-stenosis in coronary artery rack

A technology for eluting stents and zedoary oil, which is applied in stents, surgery, devices of human tubular structures, etc., to achieve the effects of inducing cell apoptosis, preventing restenosis, and inhibiting cell growth

Inactive Publication Date: 2008-12-10
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that zedoary oil has the effects of inhibiting tumor cell growth and inducing tumor cell apoptosis, inhibiting platelet aggregation, anti-platelet adhesion, improving hemorheology, anti-thrombosis, anti-inflammation, and anti-lipid peroxidation, but it has no effect reports on stent coating

Method used

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  • Curcuma zedoary oil controlled release elution rack for preventing and curing re-stenosis in coronary artery rack
  • Curcuma zedoary oil controlled release elution rack for preventing and curing re-stenosis in coronary artery rack
  • Curcuma zedoary oil controlled release elution rack for preventing and curing re-stenosis in coronary artery rack

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Preparation of zedoary oil controlled release elution stent

[0015] A stainless steel stent is used, and a polybutylmethacrylate / nano-silicon dioxide composite material is used as a drug-controlled release coating. First prepare 1% tetrahydrofuran solution of polybutyl methacrylate, which contains nano-silica of 25-30% polymer amount, and adds the zedoary oil medicine to the solution so that the weight ratio of medicine to polybutyl methacrylate Stir to suspend the drug in the solution, spray the suspension evenly on the stent with a spray gun, dry at 40°C, weigh accurately, and calculate the drug content per square millimeter of the stent surface. The thickness of the coating is 12-30 μm, and the drug content on the surface of the stent is 1.8-3.6 μg / mm 2 . Install the drug-eluting stent on the balloon and sterilize it with ethylene oxide for use.

[0016] The in vitro controlled release test of the zedoary oil controlled-release elution stent showed that the drug ...

Embodiment 2

[0018] Animal experiments were conducted to test the effect of zedoary oil controlled-release eluting stent on intimal hyperplasia after stenting in experimental animals, and to evaluate the safety and efficacy of zedoary oil controlled-release eluting stent in preventing restenosis after stenting.

[0019] Healthy hybrid adult dogs were randomly divided into 2 groups: according to the ratio of stent diameter and coronary artery diameter of 1.2 to 1.3:1, the simple coating stent and the curcuma oil controlled-release eluting stent of Example 1, the coating thickness of which was 12 μm, and the stent Surface drug content 1.8μg / mm 2 Appropriate blood vessel segments of the circumflex and anterior descending branches were randomly implanted into the coating group and the zedoary oil group, with 10 rats in each group. They began to take aspirin 250 mg one day before the operation, and were killed until 30 days later. The heart, liver, spleen, lung, kidney, stomach, brain, skeletal...

Embodiment 3

[0035] Healthy hybrid adult dogs were randomly divided into two groups: according to the ratio of stent diameter and coronary artery diameter of 1.2 to 1.3:1, the simple coating stent and the zedoary oil controlled-release elution stent of Example 1, the coating thickness of which was 30 μm, and the stent Surface drug content 3.6μg / mm 2 Randomly implant suitable blood vessel segments of the circumflex branch and anterior descending branch, namely coating group and zedoary oil group, 10 rats in each group, start taking aspirin 250mg 1 day before the operation, and kill them until 30 days, take the stent implanted into the blood vessel, The heart, liver, spleen, lung, kidney, stomach, brain, skeletal muscle, testis and other vital organs of two animals were taken and fixed.

[0036] Optical microscope and scanning electron microscope were used to observe the histopathological changes of stented vessel segments and important organs in each group. Computer images were used to qua...

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Abstract

The present invention belongs to the field of medicine and medical equipment, relates to medicine eluted rack for preventing and treating re-stenosis inside rack, and is especially curcuma zedoary oil controlled releasing elution rack for preventing and treating re-stenosis inside coronary artery rack. The rack has curcuma zedoary oil as effective medicine component, rack of stainless steel, and composite polybutyl methylacrylate / nanometer silica material as controlled releasing coating. The rack of the present invention has the functions of inhibiting cell growth, inducing apoptosis, resisting inflammation, resisting thrombosis, inhibiting collagen synthesis and resisting proliferation for long time; has excellent tissue compatibility with coronary artery and excellent safety; and can prevent and treat the re-stenosis of the rack operation.

Description

technical field [0001] The invention belongs to the field of drugs and medical devices, and relates to a drug-eluting stent for preventing restenosis in a stent, in particular to a zedoary oil controlled-release eluting stent for preventing restenosis in a coronary stent. Background technique [0002] Coronary intervention (PCI) is an important treatment for coronary heart disease. At present, stent implantation has replaced balloon dilatation as the main method of PCI. According to statistics, more than 1,500,000 patients around the world need to undergo PCI treatment every year, but the rate of restenosis after stenting is as high as 15-30%. Therefore, the prevention and treatment of restenosis after stents has become the focus and hotspot in the field of PCI research. According to reports, clinically commonly used cutting balloon dilatation, directional rotary cutting, laser shaping, gene therapy, systemic drug administration, etc. are all unsatisfactory in the treatmen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/06A61M29/00A61F2/82
Inventor 赵军礼孙宝贵钟伟
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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