Two-step method oriented synthesis of sucrose-6-higher fatty acid monoester

Abstract

The invention relates to a method for using tow-step to oriented synthesis sucrose -6-higher fatty acid monoesters. It is characterized in that the first step: using chemical synthesis method to synthesis the sucrose-6-acetate or benzoate, so that the hydroxyl of the 6 bit of the sucrose actives; the second step: it uses enzyme catalysis, higher fatty acid or methyl ester and ethyl ester and sucrose -6-acetate or benzoate to do ester exchange reaction to directional or cheesed synthesis oriented synthesis sucrose -6-higher fatty acid monoesters.

Description

technical field [0001] The invention relates to a two-step method for directional synthesis of sucrose-6-higher fatty acid monoester. Background technique [0002] Sucrose has eight hydroxyl groups, each of which can be acylated by an electrophile to produce sucrose esters with different degrees of substitution. Sucrose esters with different degrees of substitution have been widely used in industries such as detergents, food, cosmetics and medicine. The preparation method of sucrose fatty acid ester can be divided into chemical synthesis method and enzymatic synthesis method. In view of the relatively high synthesis efficiency of chemical synthesis, but the degree of esterification of sucrose is difficult to control, more and more researchers are paying more attention to the use of enzymes as catalysts to selectively synthesize sucrose higher fatty acid monoesters and control the degree of esterification of sucrose; However, the common enzymatic method directly utilizes su...

AI Technical Summary

Problems solved by technology

In view of the relatively high synthesis efficiency of chemical synthesis, but the degree of esterification of sucrose is difficult to control, more and more researchers are paying more attention to the use of enzymes as catalysts to selectively synthesize sucrose higher fatty acid monoesters and control the degree of esterification of sucrose; However, the common enzymatic method directly uses sucrose and corresponding fatty acid derivatives for enzymatic transesterification to prepare sucrose fatty acid monoesters, and the esterification site of sucrose is difficult to carry out precise and directional synthesis.

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