Photo-electro-chemical method for detecting nucleic acid

A photoelectrochemical and nucleic acid technology, applied in biochemical equipment and methods, measuring devices, scientific instruments, etc., can solve problems such as limited detection range and limited selection range of signal molecules
CN100575954CInactive Publication Date: 2009-12-30RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
Publication Date
2009-12-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for detecting nucleic acid alkali group with optical electric chemical technique, wherein said method comprises: a, contacting the tested sample and the material with optical electric chemical activity; b, evaluating the oxidization and reduction reaction between the nucleic acid alkali group and said optical electric chemical material, that using light to transform the optical electric chemical material into exciting state with existed electrode, and processing oxidization reduction reaction with nucleic acid alkali group when the excited material loses electrons, to evaluate the current generated in oxidization reduction reaction; c, based on said current, analyzing the sample qualitative or quantitatively. The invention can be used in biological detection, as nucleic acid cross detection, nucleic hurt detection and chemical material gene toxicity detection.
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Description

technical field

[0001] The invention relates to the technical field of nucleic acid detection, in particular to a method for qualitatively and quantitatively detecting nucleic acid hybridization and damage using photoelectrochemistry. technical background

[0002] It is known that human diseases are directly or indirectly related to genes. Therefore, there is an increasingly urgent demand for highly sensitive and highly selective rapid detection methods for nucleic acids, which are of great importance for gene research, drug screening, clinical diagnosis and Ecotoxicology research, toxicity screening of new compounds, and monitoring of biological pollutants in the environment all have practical significance.

[0003] Many detection methods have been used to detect nucleic acids, for example, Southern blotting, Northern blotting and PCR techniques commonly used in nucleic acid detection at present. A common point in the operation of these methods is that unhybridized probes a...

Claims

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