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Method for identifying codonopsis pilosula and preparation containing codonopsis pilosula

A technology of Codonopsis pilosula and preparations, applied in the field of quality control of pharmaceutical preparations, can solve problems such as long time consumption, and achieve the effects of low price, short development time, and easy availability of materials

Inactive Publication Date: 2007-12-12
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is easy to operate and easy to master. Its shortcoming is that it takes a long time, and it takes about 1.5 hours from spotting to fully unfolding.

Method used

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  • Method for identifying codonopsis pilosula and preparation containing codonopsis pilosula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take the Shenqi Fuzheng freeze-dried powder (prepared according to the method of Example 1 of Chinese patent application CN 15461 52A), add 30ml methanol, sonicate for 30min, filter, concentrate the filtrate to dryness, add 2ml of water to the residue to dissolve, add to C 18 The solid phase extraction cartridge (500mg, pre-washed with 8ml methanol and 20% methanol each) was eluted with 5ml 20% methanol and 3ml 50% methanol successively, and the 50% methanol eluate was collected as the test solution. Take 2g of Codonopsis pilosula reference medicinal material, and make a solution of Dangshen reference medicinal material in the same way. According to thin-layer chromatography (Chinese Pharmacopoeia 2005 Edition One Appendix VI B) test, draw 5-10μl each of the test solution and the control medicinal solution, and spot them on the same silica gel G plate, and use chloroform-methanol-water (6.5:3.5) :1, the lower layer) is a developing agent, unfold, take out, dry, spray with 1...

Embodiment 2

[0020] The test product was Shenqi Wuweizi tablets (the first part of the 2005 edition of the Chinese Pharmacopoeia), and the operation process was the same as in Example 1. In the chromatogram of the test product, at least one fluorescent spot of the same color is displayed on the corresponding position of the chromatogram of the control medicinal material.

Embodiment 3

[0022] The test product was Weishuning granules (the first part of the 2005 edition of the Chinese Pharmacopoeia), and the operation process was the same as in Example 1. In the chromatogram of the test product, at least one fluorescent spot of the same color is displayed on the corresponding position of the chromatogram of the control medicinal material.

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Abstract

The invention provides a rapid method with low cost for discriminating medicinal herb of radix codonopsitis, extract of radix codonopsitis and preparation containing radix codonopsitis. The method comprises the following steps: a preparing medicinal herb of radix codonopsitis, extract of radix codonopsitis or preparation of radix codonopsitis into proper aqueous solution, loading on C18 solid phase extraction columella, eluting with 15-30% lower alcohol and 35-85% lower alcohol in sequence, collecting eluant of 35-85% lower alcohol, concentrating or directly using as testing solution for assay; b preparing contrast medicinal herb of radix codonopsitis into contrast solution according to preparation method of testing solution for assay; sucking testing solution for assay and contrast solution, dotting on the same silica gel g plate respectively, developing with chloroform-methanol-water with ratio of 3-10:1-6:1 as developer, taking out, air-drying, and developing; wherein steps a and b has no precedence order.

Description

Technical field [0001] The invention relates to a quality control method of traditional Chinese medicinal materials and pharmaceutical preparations containing the medicinal materials, in particular to a quality control method of traditional Chinese medicinal materials Codonopsis pilosula and drug preparations containing Codonopsis pilosula or an extract of Codonopsis pilosa. Background technique [0002] Codonopsis is Codonopsis pilosula Nannf., Codonopsis pilosula Nannf.Var.modesta LTShen, Codonopsis tangshen Oliv., Codonopsis tubulosa Komar., Codonopsis tubulosa Komar. (Codonopsis subglobosa W.W.Smith) and Codonopsis canescens Nannf. The roots are sweet, calm in nature, return to the spleen and lung meridian, which are traditional Chinese medicines for invigorating qi. At present, a considerable part of the Chinese patent medicines and botanicals that have been on the market at home and abroad contain Codonopsis or Codonopsis pilosula extract, so the rapid and accurate identifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/344G01N30/94A61K125/00
Inventor 夏忠庭叶正良郑永锋李学敏
Owner TIANJIN TASLY ZHIJIAO PHARMA
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