Compound red sage root freezing-dried powder injection containing tanshinol and its preparation method

A technology of freeze-dried powder injection and compound Salvia miltiorrhiza, applied in the field of medicine, can solve the problems of large dosage, inconvenience to carry, slow onset of effect, etc.

Inactive Publication Date: 2007-12-12
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing Chinese patent medicines are mainly decoctions and compound pills, wh

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0174] Example 1:

[0175] a. Take 1000g of Salvia miltiorrhiza, 850g of Panax notoginseng, and 5g of borneol for use;

[0176] b. The above Salvia miltiorrhiza and Panax notoginseng were extracted twice with water for 1 hour each time, and the extracts were combined and concentrated to obtain Salvia miltiorrhiza extract and Panax notoginseng extract; borneol was dissolved in an appropriate amount of ethanol, and β-cyclodextrin was used for inclusion;

[0177] Dissolve Salvia miltiorrhiza extract and Panax notoginseng extract with appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, and freeze-dried , that is.

[0178] According to high performance liquid chromatography (Appendix VI D of Chinese Pharmacopoeia 2005 edition), the content of Danshensu in freeze-dried powder injection was determined;

[0179] Chromatographic conditions and ...

Example Embodiment

[0183] Example 2:

[0184] a. Take 4000g of Salvia miltiorrhiza, 260g of Panax notoginseng, and 50g of borneol for use;

[0185] b. The above Salvia miltiorrhiza and Panax notoginseng are extracted with ethanol respectively to obtain Salvia miltiorrhiza extract and Panax notoginseng extract; borneol is dissolved with an appropriate amount of ethanol and enclosed with β-cyclodextrin;

[0186] Dissolve Salvia miltiorrhiza extract and Panax notoginseng extract with appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, and freeze-dried , that is.

[0187] Measure the content according to the method of Example 1, this product contains Danshen with Danshensu (C 9 H 10 O 5 ), the content is 5.25~38.75mg / g lyophilized powder solid.

Example Embodiment

[0188] Example 3:

[0189] a. Take 1200g of Salvia miltiorrhiza, 300g of Panax notoginseng, and 6g of borneol for use;

[0190] b. The above Salvia miltiorrhiza and Panax notoginseng are respectively extracted with water, 3 times of alcohol precipitation, the extracts are combined and concentrated to obtain salvia miltiorrhiza extract and Panax notoginseng extract; borneol is dissolved with an appropriate amount of ethanol, and β-cyclodextrin is used for inclusion;

[0191] Dissolve Salvia miltiorrhiza extract and Panax notoginseng extract with appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, and freeze-dried , that is.

[0192] Measure the content according to the method of Example 1, this product contains Danshen with Danshensu (C 9 H 10 O 5 ), the content is 2.25~24.15mg / g lyophilized powder solid.

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PUM

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Abstract

The invention provides a compound red sage root freeze dried powder injection containing Danshensu and its preparing process, wherein the injection comprises red sage root, notoginseng and borneol. The preparing process consists of extracting root of red rooted saliva and pseudo-ginseng to obtain red sage root extract and pseudo-ginseng extract, dissolving baras camphor with right amount of ethanol, coating with beta-cyclodextrin, charging injection for water into red sage root extract, notoginseng or red sage root and notoginseng extracts for dissolving, boiling, cooling down, filtering, mixing filtrate with baras camphor beta-CD inclusion solution, charging mannitol, adding right amount of water for injection, adjusting pH, and finally freeze-drying. In the freeze dried injection, Calculated by the total amount of ginseng saponin Rg1 (C27H32O16), ginseng saponin Rb1 and notoginseng saponin R1, the total content of notoginseng active constituent is 12.5-50.0mg/g freeze-dried powder solid.

Description

technical field [0001] The invention belongs to the field of medicine, and more specifically relates to a compound salvia miltiorrhiza freeze-dried powder injection made from traditional Chinese medicines. Background technique [0002] In most western countries, the death of cardiovascular disease accounts for about half of the total number of deaths, among which coronary heart disease takes the first place, accounting for more than 50% of the number of cardiovascular deaths. As an Asian country, coronary heart disease is not as common in China as in European and American countries, but it has increased in recent years. According to the vital statistics released by the Ministry of Health, in 1957 urban residents died of cardiovascular and cerebrovascular diseases accounted for 12.0% of the total, which rose to 16.6% in 1989, and the ranking of the cause of death rose from the 5th and 7th to the 2nd and 3rd. It can be seen that the incidence of coronary heart disease is incr...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/19A61P9/10G01N30/02G01N33/15A61K31/045
Inventor 叶正良李永强郑永锋周桂荣
Owner TIANJIN TASLY ZHIJIAO PHARMA
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