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Pharmaceutical composition for cardiovascular and cerebrovascular diseases and method for preparing the same

A technology for cardiovascular and cerebrovascular diseases and a composition is applied in the field of medicine to achieve the effects of reducing left ventricular end-diastolic pressure, simple and easy preparation process, and reducing cardiac preload

Inactive Publication Date: 2008-04-02
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, using the interaction between Danshen or Danshen extract and Trichosanthes or Trichosanthes extract to prepare prescriptions for treating cardiovascular and cerebrovascular diseases has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Example 1 Salvia miltiorrhiza extract extraction process and preparation

[0105] Preparation of Salvia Miltiorrhiza Extract:

[0106] Take Danshen medicinal material, crush it into coarse powder, add water to decoct twice, add 12 times of water for the first time, add 10 times of water for the first time, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to relative density under reduced pressure 1.10~1.15 (60°C) concentrated solution, add ethanol until the alcohol content reaches 85%, refrigerate for 24 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add hydrochloric acid to adjust the pH value to 2, shake with ethyl acetate Extracted 3 times, combined ethyl acetate solution, and evaporated to dryness. The residue was dissolved in acidic water with a pH value of 2, added to the treated polyamide column, first eluted with 2 times the column volume of water, discarded the water washing solution, and...

Embodiment 2

[0119] Example 2 Extraction process and preparation of Trichosanthes quince extract

[0120] Preparation of Trichosanthes extract:

[0121] Take Trichosanthes medicinal material, dry, crush into coarse powder, add water to reflux and extract twice, add 10 times the amount of water each time, reflux extract for 2 hours, filter, combine filtrates, concentrate to a relative density of 1.10-1.15 (60°C ) concentrated solution, add ethanol until the content reaches 80%, leave it overnight, take the supernatant overnight, recycle the ethanol until it has no alcohol smell, concentrate under reduced pressure to a thick paste, and vacuum dry to obtain the crude extract of Trichosanthes trichosanthes.

[0122] After dissolving the above-mentioned Trichosanthes quinquefolius extract with an appropriate amount of water, shake and extract twice with an equal amount of petroleum ether, shake and extract the water liquid three times with an equal amount of water-saturated n-butanol, combine...

Embodiment 3

[0130] Embodiment 3: the preparation of red melon composition powder injection

[0131] Prescription 1:

[0132] Salvia miltiorrhiza extract 40g (equivalent to 2kg of raw medicinal materials)

[0133] Trichosanthes extract 1000g (equivalent to 15kg of raw medicinal materials)

[0134] Mannitol 300g

[0135] Add sterile water for injection to 3000ml

[0136]

[0137] A total of 1000 sticks were prepared

[0138] Prescription 2:

[0139] Salvia miltiorrhiza extract 80g (equivalent to 4kg of raw medicinal materials)

[0140] Trichosanthes extract 300g (equivalent to 10kg of raw medicinal materials)

[0141] Mannitol 300g

[0142] Add sterile water for injection to 3000ml

[0143]

[0144] A total of 1000 sticks were prepared

[0145] Prescription 3:

[0146] Salvia miltiorrhiza extract 200g (equivalent to 10kg of raw medicinal materials)

[0147] Trichosanthes extract 150g (equ...

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PUM

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Abstract

The invention belongs to the medical technical field and discloses a drug combination, which is made from a danshen root and a snakegourd fruit according to certain proportion and is used for remedying the cardio-cerebrovascular disease and the preparation, which contains the drug combination and the preparation method. The drug combination can be made into any preparation, which is acceptable in the clinic or the pharmacy, and the injection preparation and the oral preparation are preferential. The danshen root in the drug combination can be replaced by danshen root extract; the snakegourd fruit can be replaced by snakegourd fruit extract, and the danshen root extract and the snakegourd fruit extract can be directly put as the raw materials. The drug combination has the synergistic interaction effect with the good stability, and the effect is improved greatly than singly using the danshen root extract or the snakegourd fruit extract.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of salvia miltiorrhiza or its extract and trichosanthes or its extract for cardiovascular and cerebrovascular diseases, a preparation method thereof and a preparation containing the pharmaceutical composition. [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been the enemy that threatens human health. With the improvement of material living standards and changes in lifestyle in our country, and my country's gradual entry into the elderly society, the threat of cardiovascular and cerebrovascular diseases is becoming more and more serious. The current epidemic The results of the disease survey show that cardiovascular and cerebrovascular diseases are the primary diseases that threaten the health of the Chinese population, especially the age of onset and death is increasingly younger, and how to effectively prevent a...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P9/10A61P9/12A61P7/02A61P3/06
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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