Pharmaceutical composition for cardiovascular and cerebrovascular diseases and method for preparing the same

A technology for cardiovascular and cerebrovascular diseases and compositions, applied in the field of medicine, to achieve the effects of high content, increase coronary blood flow, and wide application prospects

Inactive Publication Date: 2011-07-20
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, using the interaction between Danshen or Danshen extract and Trichosanthes or Trichosanthes extract to prepare prescriptions for treating cardiovascular and cerebrovascular diseases has not been reported yet.

Method used

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  • Pharmaceutical composition for cardiovascular and cerebrovascular diseases and method for preparing the same
  • Pharmaceutical composition for cardiovascular and cerebrovascular diseases and method for preparing the same
  • Pharmaceutical composition for cardiovascular and cerebrovascular diseases and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Example 1 Extraction process and preparation of salvia miltiorrhiza extract

[0105] Preparation of Salvia miltiorrhiza extract:

[0106] Take Danshen medicinal materials, crush them into coarse powder, add water to decoct twice, add 12 times the amount of water for the first time, add 10 times the amount of water for the first time, 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density 1.10~1.15 (60℃) concentrate, add ethanol to 85% alcohol content, refrigerate for 24 hours, filter, the filtrate recovers ethanol until no alcohol smell, add hydrochloric acid to adjust the PH value to 2, shake with ethyl acetate Extract 3 times, combine the ethyl acetate solution, and evaporate to dryness. The residue is dissolved in acid water with pH 2 and added to the treated polyamide column, first eluted with 2 column volumes of water, discarded the washing liquid, and then eluted with 4 column volumes of 95% ethanol...

Embodiment 2

[0119] Example 2 Extraction process and preparation of Fructus Trichosanthis extract

[0120] Preparation of Fructus Trichosanthis extract:

[0121] Take Gualou medicinal materials, dry, pulverize into coarse powder, add water and reflux for extraction twice, add 10 times the amount of water each time, reflux and extract for 2 hours, filter, combine the filtrate, and concentrate to a relative density of 1.10~1.15 (60℃) ), add ethanol to the content of 80%, let it stand overnight, take the supernatant, recover the ethanol until there is no alcohol taste, concentrate under reduced pressure to a thick paste, and vacuum dry to obtain a crude extract of Trichosanthis.

[0122] After dissolving the above-mentioned fennel extract with an appropriate amount of water, shake and extract 2 times with an equal amount of petroleum ether, shake and extract the aqueous solution 3 times with an equal amount of water-saturated n-butanol, combine the n-butanol extracts and concentrate to dryness. Ad...

Embodiment 3

[0130] Example 3: Preparation of Dangua composition powder injection

[0131] Prescription 1:

[0132] Danshen extract 40g (equivalent to 2kg of original medicinal material)

[0133] Fructus Trichosanthis extract 1000g (equivalent to 15kg of original medicinal material)

[0134] Mannitol 300g

[0135] Sterile water for injection up to 3000ml

[0136] 1000 pieces in total

[0137] Prescription 2:

[0138] Salvia miltiorrhiza extract 80g (equivalent to 4kg of original medicinal material)

[0139] Trichosanthis extract 300g (equivalent to 10kg of original medicinal material)

[0140] Mannitol 300g

[0141] Sterile water for injection up to 3000ml

[0142] 1000 pieces in total

[0143] Prescription 3:

[0144] Salvia miltiorrhiza extract 200g (equivalent to 10kg of original medicinal material)

[0145] Fructus Trichosanthis extract 150g (equivalent to 5kg of original medicinal material)

[0146] Mannitol 300g

[0147] Sterile water for injection up to 3000ml

[0148] 1000 pieces in total

[0149] Prescr...

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PUM

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Abstract

The invention belongs to the medical technical field and discloses a drug combination, which is made from a danshen root and a snakegourd fruit according to certain proportion and is used for remedying the cardio-cerebrovascular disease and the preparation, which contains the drug combination and the preparation method. The drug combination can be made into any preparation, which is acceptable inthe clinic or the pharmacy, and the injection preparation and the oral preparation are preferential. The danshen root in the drug combination can be replaced by danshen root extract; the snakegourd fruit can be replaced by snakegourd fruit extract, and the danshen root extract and the snakegourd fruit extract can be directly put as the raw materials. The drug combination has the synergistic interaction effect with the good stability, and the effect is improved greatly than singly using the danshen root extract or the snakegourd fruit extract.

Description

[Technical Field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of Salvia miltiorrhiza or its extract and Trichoderma or its extract for cardiovascular and cerebrovascular diseases, a preparation method thereof, and a preparation containing the pharmaceutical composition. [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been a major enemy threatening human health. In my country, with the year-on-year improvement of material living standards, changes in lifestyles, and my country's gradual entry into the elderly society, the threat of cardiovascular and cerebrovascular diseases is becoming more and more serious. The results of the disease investigation show that cardiovascular and cerebrovascular diseases have become the primary disease threatening the health of the Chinese population. In particular, the age of onset and death is becoming younger, and how to effectively prevent and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K36/53A61K36/428A61P9/10A61P9/12A61P7/02A61P3/06
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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