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Method for obtaining the extraction from caper medicinal part and application of the extraction

A technology of medicinal parts and extracts, applied in the field of natural medicinal chemistry, can solve the problems of ineffectiveness of rheumatoid arthritis models and achieve the effect of low toxicity

Inactive Publication Date: 2008-05-28
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, trials have shown that the ethyl acetate and n-butanol fractions are not effective in the type II collagen-induced rheumatoid arthritis model

Method used

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  • Method for obtaining the extraction from caper medicinal part and application of the extraction
  • Method for obtaining the extraction from caper medicinal part and application of the extraction
  • Method for obtaining the extraction from caper medicinal part and application of the extraction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Crush 2 kg of caper fruits, stems and leaves, and root bark, heat and reflux with 20 liters of 75% ethanol, and extract by cold soaking, extract twice, and the extraction time is 2 hours, combine the extracts, and store the extracts at 40°C Concentrate under reduced pressure to obtain the capers anti-arthritic crude extract extract;

[0023] Degrease the crude extract extract with petroleum ether successively, and extract the residue with chloroform to obtain compound extracts.

Embodiment 2

[0025] Crush 5 kg of caper fruits, stems and leaves, and root bark, heat and reflux with 100 liters of 70% ethanol, extract by percolation, extract twice, the extraction time is 5 hours, combine the extracts, and depressurize the extracts at 45°C Concentrate to get caper anti-arthritic crude extract extract;

[0026] Degrease the crude extract extract with petroleum ether successively, and extract the residue with chloroform to obtain compound extracts.

Embodiment 3

[0028] Crush 3 kg of caper fruits, stems and leaves, and root bark, heat and reflux with 45 liters of 80% ethanol, extract by cold soaking, extract once, the extraction time is 10 hours, combine the extracts, and depressurize the extracts at 50°C Concentrate to get caper anti-arthritic crude extract extract;

[0029] Degrease the crude extract extract with petroleum ether successively, and extract the residue with chloroform to obtain compound extracts.

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Abstract

The invention discloses a method of obtaining extract from the medical part of capparis spinosa L. This method includes the following steps: the medicinal part of capparis spinosa L. is pulverized; the crude extracts is obtained through heating reflux, cold soaking, percolate extraction and decompressed concentration. The crude extract is defatted by ligroin, and the invention is characterized in that the residue after defatting is extracted by chloroform to get the extract. This extract is used for treating rheumatic arthritis, rheumatoid arthritis and periarthritis of shoulder. Pharmacodynamics study demonstrates that the extract obtained from the invention has obvious curative effect on multiple arthritis models (including type collagen II induced rheumatoid arthritis models).

Description

technical field [0001] The invention relates to the field of natural medicinal chemistry, in particular to a method for obtaining an extract from capers and the application of the extract. Background technique [0002] Capers are Capparis spinoa L, a plant of the cauliflower family, also known as mallet fruit vine, mouse melon, wild watermelon, pineapple fruit, etc. Capers are a kind of semi-shrubs that grow in hot and arid climate conditions. In my country, they are mainly distributed in low rocky mountains, hilly slopes, gullies at the foot of mountains or Gobi Desert in the north and south of Tianshan Mountains in Xinjiang. In addition, it also grows in Gansu, Tibet and other places. Capers are mainly distributed in the Mediterranean Gulf region abroad, and the growth period is from May to October. The medicinal parts of capers are leaves, fruit and root bark. It tastes pungent and warm in nature. Folks use capers to treat arthritis, ventilation and other diseases, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P29/00A61P19/02A61K125/00A61K127/00A61K131/00
Inventor 李晶晶肖璘吴彤李燕刘英孙海燕吴学军刘珉宇贺兴冬刘全海蔡立姜仁吉
Owner SHANGHAI INST OF PHARMA IND
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