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Application of cinnamic aldehyde in alpha-glucosidase restrainer

A technology of glucosidase and cinnamic aldehyde, which is applied in the directions of pill delivery, aldehyde active ingredient, bulk delivery, etc., can solve the problems such as no reports on the inhibitory effect of cinnamic aldehyde α-glucosidase.

Inactive Publication Date: 2008-06-11
INST OF CROP SCI CHINESE ACAD OF AGRI SCI
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  • Abstract
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Problems solved by technology

[0006] There is no report on the inhibitory effect of cinnamic aldehyde α-glucosidase

Method used

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  • Application of cinnamic aldehyde in alpha-glucosidase restrainer

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Experimental program
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Embodiment Construction

[0011] Preparation of the test solution: 0.7mL of 0.06mol / L maltose solution, then add 0.2mL of cinnamon aldehyde solution diluted to different concentrations, 0.1mL of 20mg / mL α-glucosidase solution, heat in 37°C water bath for 15min, add pH 7.0 Tris-Hcl buffer 1.5mL to stop the reaction. Take 50 μL of it and add 200 μL of glucose chromogen, heat in a water bath at 37°C for 30 min, and measure the absorbance value at 490 nm.

[0012] Preparation of blank solution: pH 7.0 phosphate buffer solution 0.7mL instead of maltose solution, the same as the preparation of the test solution.

[0013] Preparation of the control solution: 0.2 mL of dimethyl sulfoxide was used to replace the cinnamon aldehyde solution, and the rest of the operations were the same as the preparation of the test solution.

[0014] Positive control: the phosphate buffer solution with a pH of 7.0 was used to prepare solutions with a series of concentrations for Baisupine, and the experimental operation was the...

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Abstract

The invention provides a new alpha-glucosidase inhibitor which comes from cinnamomum cassia which is a traditional Chinese medicine, namely cinnamic aldehyde, and an application of the cinnamic aldehyde in preparing medicament for preventing and curing diabetes, abnormal glucose tolerance and adiposis and the like, or health products.

Description

technical field [0001] The invention relates to an α-glucosidase inhibitor containing cinnamic aldehyde as an active ingredient, which can be used in medicines or health care products, and belongs to the field of traditional Chinese medicines. Background technique [0002] In recent years, with the improvement of people's living standards and the acceleration of the pace of life, the incidence of hypertension, diabetes, arteriosclerosis, obesity and other diseases has increased year by year. Hypertension, diabetes and cardiovascular disease have become three major diseases that seriously endanger people's health. Common diseases, especially high blood pressure and diabetes, have a higher incidence rate among middle-aged, elderly people and mental workers. α-glucosidase widely distributed in organisms, such as maltase, sucrase, isomerized maltase, and lactase, is distributed on the brush-shaped edge of the small intestinal epithelial chorion, and plays an important role in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/11A61K9/16A61K9/20A61K9/48A61P3/10
Inventor 任贵兴平华张瑞
Owner INST OF CROP SCI CHINESE ACAD OF AGRI SCI
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