Method for determining index composition content of Qingkailing injection intermediate body and finished product
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A measurement method and injection technology, applied in the direction of measuring devices, material separation, analysis of materials, etc., can solve time-consuming and other problems
Inactive Publication Date: 2008-07-30
BEIJING UNIV OF CHINESE MEDICINE
View PDF2 Cites 7 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0003] In order to overcome the time-consuming shortcomings of the existing detection methods and realize the on-line detection of the index components in the intermediates and finished products of Qingkailing injection, the present invention uses ultraviolet spectroscopy combined with chemometrics such as partial least squares method for analysis and data analysis. Processing, not only fast and convenient, but also accurate and reliable
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0108] Embodiment 1: the method for the content of chlorogenic acid and baicalin in Yinhuang liquid measured by ultraviolet spectrometry
[0109] Yinhuang liquid is one of the intermediates in the production process of Qingkailing injection. It is made by mixing honeysuckle water extract and baicalin aqueous solution in a certain proportion. The quality index components are chlorogenic acid and baicalin.
[0110] 1 Determination method of chlorogenic acid and baicalin in Yinhuang liquid.
[0111] 1.1 Instrument: Agilent 1100 high performance liquid chromatography (Agilent, USA), including: quaternary pump, vacuum degassing pump, autosampler, column thermostat, DAD diode array detector, HP data processing workstation;
[0112] 1.2 Reagents: Chlorogenic acid and baicalin reference substances were purchased from China National Institute of Pharmaceutical and Biological Products (batch numbers 110753-200212 and 110715-200212 respectively); Yinhuang liquid was provided by a designa...
Embodiment 2
[0237] Embodiment 2: the method for measuring geniposide and total nitrogen content in four mixed liquids by ultraviolet spectrometry:
[0238] The four mixed liquid is one of the intermediates in the production process of Qingkailing injection. It is made by mixing the hydrolyzate of mother of pearl and buffalo horn, the water extract of isatidis root and the water extract of gardenia by a certain process. The quality index component is gardenia Glycosides and total nitrogen.
[0239] 1 Determination of the content of geniposide and total nitrogen in the four-mixture:
[0240] 1.1 Instruments: Agilent 1100 high performance liquid chromatography (Agilent, USA), including: quaternary pump, vacuum degassing pump, autosampler, column thermostat, DAD diode array detector, HP data processing workstation; KDY nitrogen determination Instrument (Shanghai Ruizheng Instrument Equipment Co., Ltd.);
[0241] 1.2 Reagent: The reference substance of geniposide was purchased from China Nat...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a method for measuring index component content in a Qingkailing injection midbody and a finish product. The invention is characterized in that each index component content is measured by adopting the high performance liquid chromatography or other analysis methods; the diluted sample is scanned in full wavelength by adopting the ultraviolet spectrophotometric method; the sample is divided into two parts: a corrected collection and a verified collection. According to the ultraviolet spectroscopic data and the content of the corrected collection, the data are processed by adopting the chemometrics method; a mathematical model is established by utilizing a TQ Analyst software and a Matlab 6.5 software; the ultraviolet spectroscopic data of the verified collection sample is substituted into the mathematical model; a predicted value and a true value are compared, and the precision and the reliability of the technology are verified. The method of the invention can be used for content measurement of chlorogenic acid and baicalin in the silver yellow liquid, and the content measurement of Caryptoside and total nitrogen in the four-miscible liquid. The invention also can be used for the fast online detection of component content hereinbefore, and can be used for the content measurement and fast online detection of the Qingkailing injection midbody and the finish product.
Description
technical field [0001] The present invention relates to a rapid determination method for the content of index components in intermediates and finished products in the production process of Qingkailing injection, more specifically, it relates to an ultraviolet spectrum determination method for the content of chlorogenic acid and baicalin in Yinhuang liquid. The ultraviolet spectroscopic determination method of the content of glycosides and total nitrogen relates to the determination method of the content of chlorogenic acid and baicalin in Yinhuang liquid, an intermediate in the production process of Qingkailing injection, or the green The on-line detection method for the content of ortho acid and baicalin relates to the on-line detection method for the content of geniposide and total nitrogen in the four-mixed liquid intermediate in the production process of Qingkailing injection. Background technique [0002] Qingkailing Injection is a modern traditional Chinese medicine in...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more