Check patentability & draft patents in minutes with Patsnap Eureka AI!

Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus

A technology for markers and diabetes, applied in the diagnosis of susceptibility to type 2 diabetes, diagnosis of protection against type 2 diabetes, diagnosis of type 2 diabetes susceptibility reduction, and can solve problems such as unsatisfied

Inactive Publication Date: 2008-08-06
DECODE GENETICS EHF
View PDF48 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The high prevalence of this disease and the increasing size of the affected population indicate that there is an unmet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus
  • Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0181]Described here is the identification of transcription factor 7-like 2 (TCF7L2-formerly TCF4) as a gene contributing to type 2 diabetes risk by single point association analysis using dense microsatellite markers within the 10q locus.

[0182] method

[0183] iceland group

[0184] The Data Protection Authority of Iceland and the National Bioethics Committee of Iceland approved the study. All study participants signed informed consent. All personally identifiable data related to blood samples, medical information and family pedigrees are first encrypted by the Data Protection Authority using a third-party encryption system(18) (Data Protection Authority).

[0185] For the study, 2,400 patients with type 2 diabetes were identified who had either been diagnosed during a long-term epidemiological study by the Icelandic Heart Association over the past 30 years or had been diagnosed in Reykjavik over the past 12 years. (Reykjavik) was diagnosed in two major hospitals. Tw...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.

Description

Background of the invention [0001] Diabetes mellitus, a metabolic disease of decreased sugar utilization and increased lipid and protein utilization, is caused by absolute or relative deficiency of insulin. In more severe cases, diabetes is characterized by chronic hyperglycemia, glucosuria, loss of water and electrolytes, ketoacidosis, and coma. Long-term complications include neuropathy, retinopathy, nephropathy, development of systemic degeneration of large and small vessels, and increased susceptibility to infection. The most common type of diabetes is type II, non-insulin dependent diabetes, characterized by hyperglycemia resulting from impaired insulin secretion and insulin resistance in target tissues. Both genetic and environmental factors play a role in the disease. For example, obesity plays an important role in disease development. Type 2 diabetes is often a milder form of progressive onset diabetes. [0002] The health impact of type 2 diabetes is enormous. In...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12Q1/68A61P3/10
CPCC12Q1/6883C12Q1/6886C12Q2600/156C12Q2600/106C12Q2600/136C12Q2600/158C12Q2600/172A61P3/10C12N15/1006
Inventor 斯特鲁安·F·A·格兰特
Owner DECODE GENETICS EHF
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com