Anti-inflammatory compositions and methods of use

一种组合物、抗炎剂的技术，应用在具有抗炎特性的组合物领域，能够解决没有效果、缓解炎症没有等问题

Active Publication Date: 2008-10-15
JOHNSON & JOHNSON CONSUMER COPANIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many active agents or combinations thereof have little or no effect in alleviating inflammation when applied at relatively low levels

Method used

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  • Anti-inflammatory compositions and methods of use
  • Anti-inflammatory compositions and methods of use
  • Anti-inflammatory compositions and methods of use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Evaluation of RAW 264 macrophage cell line

[0024] Mononuclear phagocytes or macrophages, found in large numbers in the skin, are an important part of the natural immune response. In the skin, macrophages are mainly involved in the recognition and elimination of foreign pathogens such as bacteria by producing nitric oxide, a potent pro-inflammatory mediator. However, nitric oxide release can also lead to skin inflammation and cause damage to adjacent skin cells, and unregulated nitric oxide production can lead to tissue damage. In the following experiments, olive leaf extract, Sepcom, or the combination of olive leaf extract and Sepcom could affect the inflammatory response by reducing the activation of macrophages.

[0025] Mouse macrophage cell line (RAW264) cells were adjusted to 4×105 in DMEM containing 10% FBS (American Standard Biological Collection Center, Manassas, VA) 6 cells / ml, and then 100 μL was added to a flat-bottomed 96-well tissue culture ...

Embodiment 2

[0030] Example 2: Comparison of the strengthening effect of Sepcom on water-soluble and oil-soluble natural extracts in RAW 264 macrophage cell line

[0031] In the following tests, Sepcom was able to reduce the activity of macrophages, indicating that it synergistically enhances the anti-inflammatory capacity of water-soluble and oil-soluble extracts of natural substances.

[0032] Mouse macrophage cell line (RAW264) cells were adjusted to 4×105 in DMEM containing 10% FBS (American Standard Biological Collection Center, Manassas, VA) 6 cells / ml, and then 100 μL was added to a flat-bottomed 96-well tissue culture plate. Rat macrophages were stimulated with 0.1 μg / ml lipopolysaccharide (LPS), a component of bacterial cell wall, as a positive control; )), partially water-soluble / partially oil-soluble extracts (chamomile), oil-soluble extracts (oat oil extract, frankincense oil extract), or a combination of extracts and Sepcom to stimulate cells. Seaweed, also known as Seaweed,...

Embodiment 3

[0039] The study was conducted in four adult Caucasian women with skin types 1-3 on the Fitzpatrick scale. The use of lotions / products was not permitted in designated study areas during the trial.

[0040] The volunteer subjects' skin was allowed to dry during conditioning. Subjects were asked to follow a skin drying regimen for 7 days prior to the test. This includes washing the legs (from the knees down) with Ivory soap 2 times a day. This regimen was continued throughout the trial period.

[0041] In the study, evaluations were carried out before and 4 hours after application of a fixed amount of product. On days 1 and 3 only, irritation was induced by scraping at various sites on the legs prior to application of the product and measurements were carried out as described above. Two products were tested; one containing a composition consisting of 1.0% Sepcom, 0.01% Olive Leaf and 0.5% Coviox T90 (the "active" product) and the other a placebo product of the same formulati...

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Abstract

Provided are anti-inflammatory compositions comprising (a) an anti-inflammatory agent selected from the group consisting of olive leaf extract, holly herb, sappan wood, feverfew, and combinations of two or more thereof, and (b) an anti-inflammatory agent comprising at least one lipophilic aminoacid and at least one metal salt. Also provided are personal care products comprising such compositions,and methods of use thereof.

Description

field of invention [0001] The present invention relates to compositions having anti-inflammatory properties, and more particularly to compositions comprising a combination of anti-inflammatory agents which have unexpectedly high synergistic anti-inflammatory properties compared to conventional compositions. Background technique [0002] Many skin care actives suitable for use in personal care compositions are known. Examples of such skin care actives include olive leaf extracts, which are known to have hypotensive and hypoglycemic activity, have free radical scavenging properties when used in foods and cosmetics, and exhibit anti-inflammatory activity when administered by the oral route (e.g. , see "Oleuropein-rich olive leaf extracts, products thereof, and uses of medicaments and compositions containing components thereof", Combes, Georges; Escaut, Alexandre. French patent application, FR 2507477A119821217, 1982; Gonzalez M et al., "Hypoglycemic activity of olive leaf", Pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K33/14A61K33/24
CPCA61K36/28A61K31/198A61K36/63A61K45/06A61K33/24A61K36/53A61P17/00A61P29/00A61K2300/00
Inventor J·霍兰德J·尼古罗沃斯基P·莱特M·索斯霍V·朱
Owner JOHNSON & JOHNSON CONSUMER COPANIES
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