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Dihydrotestosterone external preparation and pharmaceutical use thereof

A kind of technology of dihydrotestosterone and preparation, applied in the field of dihydrotestosterone external preparation

Inactive Publication Date: 2008-12-31
SHANGHAI HUILUN BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are only testosterone preparations, and no dihydrotestosterone preparations are on the market

Method used

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  • Dihydrotestosterone external preparation and pharmaceutical use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Patient A, male, 22 years old, unmarried. The penis is small since childhood, and after puberty, it is smaller than peers. Begin to see a doctor until December, 2006. Occasional nocturnal erections, no spermatorrhea since childhood, sexual desire, but dare not approach women.

[0022] Through physical examination, X-ray examination, reproductive hormone examination, excitement test and other examinations, he was diagnosed as hypogonadism.

[0023] Treatment: Patient A was treated with 0.7% dihydrotestosterone gel locally, and 5g of the gel was applied to the inner thigh in the morning and evening. After one week, patient A's erection increased, and after three weeks, he occasionally had nocturnal emission. It shows that the condition has improved.

Embodiment 2

[0025] Patient B, male, 20 years old, was admitted to the hospital in 2006 due to adolescence of male secondary sexual characteristics for 6 years. The patient's breasts began to gradually increase 6 years ago, and the male secondary sexual characteristics have not appeared. He is behind his parents in height, with average intelligence, and low levels of T, FSH, LH, and DHT.

[0026] Treatment: Patient B was treated with topical 0.7% dihydrotestosterone cream, and 5g of the cream was applied to the arm once in the morning and evening. After 3 months, the DHT level recovered, and after 9 months, the secondary sexual characteristics began development. The condition is relieved.

Embodiment 3

[0028] Patient C, male, 53 years old, with age, decreased serum testosterone levels (below the lower limit of 3ng / ml), resulting in decreased serum dihydrotestosterone levels, symptoms of decreased physical strength, decreased libido, erectile dysfunction and Depression and other symptoms. Suffering from "partial androgen deficiency in middle-aged and elderly males".

[0029] Treatment: Patient C was treated with topical 0.7% dihydrotestosterone cream, and 5g of the cream was applied to the arm once in the morning and evening. After 1 month, the DHT level recovered. After 3 months, the physical strength recovered and the libido was enhanced. , in a good mood.

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Abstract

The present invention provides an external preparation of dihydrotestosterone. The preparation contains 0.01 percent to 5 percent of the dihydrotestosterone by weight percentage in a medicinal carrier of the preparation uniformly; wherein, the medicinal carrier is selected from solution, suspension, lotion, gel, ointment, cream, paste and patch. The preparation can remedy the primary, the secondary and the senile hypogonadism, the prostatic hyperplasia, the gynaecomastia and the lichen sclerosis et atrophicus. The medicated part can be arm, shoulder, inner thigh, chest, abdomen and genitalia.

Description

Technical field: [0001] The invention relates to an external preparation of dihydrotestosterone and its medicinal application. Background technique: [0002] Dihydrotestosterone is a metabolite of testosterone. In sexual organs (such as the prostate and seminal vesicles), testosterone is metabolized into dihydrotestosterone by 5-alpha reductase to play a role in the body. Dihydrotestosterone is an androgen, and it is mainly used to treat male hypogonadism and its complications caused by too little androgen secretion. Due to the "first-pass effect" of the liver, oral administration of dihydrotestosterone is ineffective; and injection administration will initially cause the concentration of dihydrotestosterone in the blood to exceed the physiological upper limit concentration, then gradually decrease, and then be lower than the physiological lower limit concentration; Testosterone is prepared into a suitable external preparation, which slowly releases dihydrotestosterone so t...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/08A61K9/06A61K9/10A61K9/70A61K31/566A61P5/26
Inventor 秦继红
Owner SHANGHAI HUILUN BIOLOGICAL TECH CO LTD
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